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Hal-abuurka Daawaynta Hidde-sidaha Waxay Rajo Cusub u fidisaa Bukaannada Sickle Cell iyo Thalassaemia

Hal-abuurka Daawaynta Hidde-sidaha Waxay Rajo Cusub u tahay Bukaannada Sickle Cell iyo Thalassaemia
FUCASO: Daawaynta Kacaanka ee Bini'aadamka Buuxda BCMA CAR-T

FUCASO: Daawaynta Kacaanka ee Bini'aadamka Buuxda BCMA CAR-T
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Dhaawaca neerfaha indhaha-01
Metastatic melanoma-04

Metastatic melanoma-04
Kansarka ugxan-03

Kansarka ugxan-03
Melanoma indhaha (bilawgii), oo ay ku xigto burooyinka beerka ee metastatic-02

Melanoma indhaha (bilawgii), oo ay ku xigto burooyinka beerka ee metastatic-02
Heerka sare ee IV kansarka mindhicirka-01

Heerka sare ee IV kansarka mindhicirka-01
Kansarka qanjirka 'prostate' ee heerka sare ah oo ay la socdaan lafo badan oo metastases-05

Kansarka qanjirka 'prostate' ee heerka sare ah oo ay la socdaan lafo badan oo metastases-05
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FUCASO: Daawaynta Kacaanka ee Bini'aadamka Buuxda BCMA CAR-T

FUCASO waa daawaynta CAR-T ee kacaanka ah ee BCMA-bartilmaameedka IASO BIO, oo bixisa waxtarka iyo badbaadada aan la soo koobi karin ee soo noqnoqda ama dib u celinaysa myeloma badan. Heerarka jawaabta sare, cafiska waara, iyo astaanta badbaadada adag, FUCASO waxay siisaa rajo cusub bukaanada waxayna dejisaa heer cusub daawaynta CAR-T.

    Nala soo xidhiidh
    faahfaahinta alaabta
    Faa'iidooyinka muhiimka ah ee FUCASO
    Guul Caafimaad

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    FUCASO, oo ay soo saartay Nanjing IASO Biotechnology, waa daawaynta CAR-T oo si gaar ah loogu talagalay in lagu beegsado antigen-ka korriinka unugyada B-cell (BCMA). Daawayntani waxay u taagan tahay waxtarkeeda caafimaad ee aan la barbar dhigi karin iyo astaanta badbaadada, taasoo siinaysa rajo cusub bukaanada qaba dib u soo noqoshada ama dib u laabashada Multiple myeloma (r/rMM). Waxaa ansixiyay Maamulka Alaabta Caafimaadka Qaranka (NMPA) Juun 30, 2023, FUCASO waxay horey u muujisay guul weyn oo ku saabsan codsiyada caafimaadka.

    Heerarka Jawaabcelinta SareFUCASO waxay ku faantaa Heerka Jawaabta Guud (ORR) ee 98.9% iyo Heerka Jawaabta Dhamaystiran (CR) ee 82.4%, oo aad uga sarreeya daawaynta kale ee la heli karo.

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    Cafis waaraBukaannada lagu daweeyay FUCASO waxay muujiyeen heerka Badbaadinta-Horumarka-La'aanta ah ee 12-bilood (PFS) ee 85.5%, taas oo muujinaysa cafiska muddada-dheer iyo tayada nolosha oo hagaagtay.

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    Xogta Badbaadada: Iyadoo ≥3 darajo Cytokine Release Syndrome (CRS) oo ku dhaca kaliya 1% bukaanada oo aan la soo sheegin kiisaska ≥3 fasalka Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), FUCASO waxay bixisaa ikhtiyaar daawaynta badbaado leh marka loo eego daawaynta kale ee CAR-T .

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    Waxtarka-kharashka: Daawaynta FUCASO aad ayey uga yar tahay daawaynta la midka ah ee laga heli karo Maraykanka, taas oo ka dhigaysa doorasho macquul ah oo loogu talagalay bukaanno kala duwan.

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    Gaaritaanka Caalamiga ah: IASO BIO waxa ay Shiinaha ka dhistay shabakad xarun daaweyneed oo dhamaystiran, awood u leh in ay u adeegto bukaanada aduunka oo dhan oo leh adeegyo isku dhafan laga bilaabo la-talin ilaa daryeelka daaweynta ka dib.

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    Bukaankii ugu horreeyay ee lagu daweeyay FUCASO waxa uu gaadhay shan sano oo badbaado la'aan ah oo kansar ah, oo ah horumar cajiib ah marka la barbar dhigo Badbaadinta Horumarka Xorta ah ee dhexdhexaadka ah (PFS) ee bilaha 2.9 oo keliya oo leh daryeel caadi ah. Tani waxay muujinaysaa awoodda FUCASO si ay u beddesho muuqaalka daaweynta ee myeloma badan.

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