Dulmar Dhamaystiran oo ku saabsan Daawaynta Cudurka Leukemia-ga ee Goosha
Tilmaamaha CAR-T
●B-cell oo ah leukemia ba'an ee lymphoblastic
●Myeloma badan
●Leukemia lymphocytic chronic
●lymphoma non-Hodgkin
●Faafi lymfoma B-cell weyn
●SLE (Lupus Erythematosus nidaamsan)
●Myasthenia gravis
●Cudurada kale ee difaaca jirka
Waxqabadka caafimaad ee CAR-T oo heersare ah
Tilmaamaha CD19+20CAR-T:Bukaanka qaba lymphoma-ka aan Hodgkin ahayn B-cell
Hal bil heerka CR | Hal bil heerka PR | Hal bil AMA qiime | CRS≥3 | CRES≥3 |
71.95% (59/82) | 25.6 (21/82) | 97.55 (80/82) | 12.19% (10/82) | 0 |
Tilmaamaha CD19+22CAR-T:Daawaynta CD19 soo noqoshada iyo dib u soo noqoshada bukaanada B-lymphocytic leukemia
Hal bil heerka CR | Hal bil heerka PR | Hal bil AMA qiime | CRS≥3 | CRES≥3 |
92.1% (35/38) | 7.9% (3/38) | 100% (38/38) | 15.79% (6/38) | 0 |
Tilmaamaha BCMACAR-T:Daaweynta myeloma badan ee soo noqnoqda iyo soo laabashada
Hal bil heerka CR | Hal bil heerka PR | Hal bil AMA qiime | CRS≥3 | CRES≥3 |
72.41% (21/29) | 27.59% (8/29) | 100% (29/29) | 6.9% (2/29) | 0 |
Faa'iidooyinkayaga
● Daawaynta ShakhsiyeedDaawaynta CAR-T kasta waxaa loo habeeyey bukaanka, iyadoo hubinaysa natiijooyinka daawaynta ee aadka loo bartilmaameedsaday.
● Ikhtiyaarada Bartilmaameedka Kala Duwan: Iyada oo tiro balaadhan oo ah antigens bartilmaameedka, oo ay ku jiraan CD7, CD19, CD20, CD22, iyo BCMA, our CAR-T alaabooyinka waxay bixiyaan kala duwanaansho aan la barbar dhigi karin ee daaweynta kala duwan ee malignancies hematological iyo cudurrada difaaca jirka.
● La Xaqiijiyay Guusha CaafimaadDaawayntayada CAR-T waxay muujiyeen waxtar aan caadi ahayn oo ku saabsan xaalado caafimaad oo badan, oo leh heerar cafis oo cajiib ah iyo muuqaalada badbaadada, xoojinta booskayaga hogaamiye ahaan immunotherapy.
● Waxtarka Qiimaha Sare: Waxaan bixinaa tartan tartan ah oo leh daaweyn tayo sare leh oo qiimo badan la heli karo marka la barbar dhigo alaabada kale ee CAR-T ee suuqa.
● Tignoolajiyada GoyntaKa faa'iidaysiga horumarradii ugu dambeeyay ee injineernimada hidde-sideyaasha, daawayntayada CAR-T waxay tilmaamaysaa mustaqbalka kansarka iyo daaweynta cudurrada difaaca jirka.
● Taageerada Caafimaad ee KhabiirkaKooxdayada khibrada leh ee dhakhaatiirta iyo cilmi-baarayaasha waxay bixiyaan daryeel dhamaystiran laga bilaabo la-talinta bilowga ah iyada oo loo marayo maamulka daawaynta iyo dabagalka.
Unugyada CAR-T ayaa hadda si weyn loogu aqoonsaday waxtarkooda bukaannada aan ka jawaabin daaweynta dhaqameed sida kiimoterabiga ama beerista dhuuxa lafta. Bulshada caafimadka caalamku waxa ay aqoonsantahay kartida asaasiga ah ee daawaynta CAR-T si ay u badasho natiijooyinka bukaanka.
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