Leukemia ba'an oo Lymphoblastic ah (T-ALL) -10

Wiil 13 jir ah oo lagu magacaabo Yangyang oo ka soo jeeda Panzhihua, ee gobolka Sichuan, ayaa maray CAR-T oo ay ku xigtay in la isku tallaalo.

Yangyang waxa uu markii hore soo bandhigay "nabaro kala firdhay oo uu weheliyo daal" April 12, 2021 Chongqing Waxa uu cusbitaal kale ku maray 3 wareeg oo kiimiko ah, laakiin dhuuxa lafta kama jawaabin. Horaantii bishii Juun, waxa ku dhacay daciifnimo labada addin ee hoose mana socon karo.

Julaay 1, 2021, Yangyang waxa la dhigey waaxdayada dhiiga ee Ward 2. Waxa uu iska diiwaan galiyey CD7 CAR-T tijaabadi kiliinikada Julaay 8 waxana uu helay faleebo unug CD7 CAR-T ah oo iskeed u gaar ah Julaay 26 si loogu daweeyo difaac. Lix iyo toban maalmood ka dib faleebo, qaab-dhismeedka dhuuxa lafta ayaa muujiyay cafis, iyo cytometry socodka ayaa tilmaamay 0.07% shakiga T lymfoblast-ka aan qaan-gaarin. Daaweynta jireed ka dib, wuxuu dib u helay awoodda uu u socdo si madaxbannaan. Maalintii 31-aad ee faleebada ka dib, dhuuxa laftiisa ayaa helay cafis dhammaystiran.

Hadda, Yangyang waxaa loo wareejiyay Ward 6 ee Waaxda Dhuuxa Lafta si loogu daweeyo. Dr. Hai oo ka socday Ward 6 ayaa sheegay in Yangyang uu si firfircoon ula shaqayn jiray oo uu rajo ka qabay intii lagu jiray daawaynta. Waxa uu maray tallaalka unugyada unugyada unugyada dhiigga cas ee allogeneic (oo ka yimid aabbihiis) Sebtembar 28. Shuruudaha ay abuureen asxaabta Waaxda Dhiigga Dhiigga ee isku xidhka tallaalka ayaa si weyn loo mahadiyay.

Bukaannadan, ka hor inta aan la diwaangelin CD7 CAR-T tijaabo caafimaad, ayaa lagu soo bandhigay calaamado kala duwan sida soo noqoshada transplant ka dib, T / myeloid dual expression, leukemia ba'an oo u adkaysta / u adkaysta T-cell leukemia, habka dhexe ee neerfayaasha leukemia, dhiigbaxa intracranial, iyo caabuq sambabada. Qiimaynta iyo daawaynta ka dib CD7 CAR-T therapy, dhamaan waxa la gaadhay cafis dhamaystiran, oo la kulmay natiijooyinkii la filayey.

Cusbitaalka Ludaopei wuxuu si firfircoon u sahamiyay dhinaca daawaynta CAR-T wuxuuna urursaday khibrad qani ah oo ku saabsan maaraynta CRS. Inta badan ka qaybgalayaasha, waxyeelada ugu daran waxay ahayd qandho sare. "Waxaan ku guuleysan karaa cafis dhammaystiran, sidaas darteed qandho maaha waxba! Waxaan rabaa in dad badan ay ogaadaan in Ludaopei uu samayn karo CAR-T!" Ayuu yiri Yangyang oo ka yimid Fujian markii la sii daayay.