Hondo yaWu: Kutambura kubva kune akawanda myeloma

Patient Wu, murume ane makore 71 okukura, akabatwa nemultiple myeloma.

Akatsvaga kurapwa kuBiocus International Medical Center muna 2022 uye akagutsikana zvakanyanya nekuchengeta kwake. Iyo yekutanga pathology yakaratidza lumbar MRI uye T5T scan yakawanikwa, kusanganisira T10, T11, uye L1 koni fractures ine bone marrow edema. Pamusoro pezvo, zvikwangwani zvidiki zvidiki zvisina kujairika zvakaonekwa muL2 vertebral body. A vertebral puncture biopsy yakasimbisa plasma cell myeloma. Dzimwe ongororo dzakaratidza prokaryotic plasma inosanganisira 46% yemapfupa emapfupa biopsy, ine masero akaiswa zvisina kujairika anoumba 14% mukuyerera cytometry. Bone junction biopsy yakaratidza 70% problastoma. Ongororo yeFISH yakaratidza kurasikirwa kwemajini mulq21 (CKSIB) uye 1m32 (CDKN2C), nepo FTSH bvunzo yaive yakanaka yep53 kudzima gene, uye ICH yaive isina kunaka muyedzo yeFISH. Kuongororwa kwekupedzisira kwaive nemultiple osteoblastic follipoma (L light chain type), ine DS staging muchikamu B, ISS staging III, uye RISS staging muStage II. Patient Wu akaratidza kutenda nerubatsiro rwakakwana uye rwemunhu rwakapihwa nenzvimbo yekurapa.

Nhoroondo yekurapa yapfuura:

Zviratidzo zvekiriniki zve multiple myeloma zvakasiyana, kunyanya kusanganisira kupererwa neropa, kurwadziwa kwepfupa, kusakwana kwerenal, utachiona, kubuda ropa, zviratidzo zvetsinga, hypercalcemia, uye amyloid stools. Chipatara chakaita zvehutsinye kurapa utachiona uye kugadzirisa kupererwa neropa uye kuderera kweplatelet. Inenge mwedzi miviri mushure meBCMA CAR-T cell infusion, zviratidzo zvemurwere zvishoma nezvishoma zvakadzokera kune zvakajairika, uye mamiriro ake akanga ari pasi pesimba. Bioocus International Medical Center yanga ichiramba ichitarisa murwere kuti ive nechokwadi chekugadzikana kwemaitiro ekurapa.