Systemic Lupus Erythematosus (SLE)-04
Pazera ramakore manomwe, Yaoyao (zita rekunyepedzera) akatanga kuona kubuda kwemapundu matsvuku pachiso chake, ayo akapararira zvishoma nezvishoma mumuviri wake wose. Pamwe chete nezviratidzo izvi, aigara achiita maronda omumukanwa uye kugara achirwadza pamajoini, zvichiita kuti mhuri yake iende kuchipatara. Mushure mekunyatsoongororwa kuchipatara, Yaoyao akaonekwa kuti ane chirwere chinonzi systemic lupus erythematosus (SLE), chirwere che autoimmune chinozivikanwa nekuoma kwacho uye kusafungidzira.
Mukati memakore matatu, Yaoyao akarapwa zvakasimba uye achiteverwa nguva dzose kuchipatara. Kunyangwe kukwira kuri kuita madosi emushonga kwava kusvika pakukwirisa, mamiriro ake airatidza kuve nani. Saizvozvo, proteinuria yake, chiratidzo chekubatanidzwa kwetsvo muSLE, yakaramba ichiwedzera, zvichikonzera kushushikana uye kunetseka pakati pemitezo yemhuri yake.
Kuburikidza nekutumirwa neshamwari yaakavimbika, Yaoyao akaunzwa kuchipatara cheLu Daopei, kwaakapinda muyedzo yekiriniki yeCAR-T. Zvichitevera kuongororwa kwakasimba, akagamuchirwa mukutongwa musi waApril 8. Zvadaro, musi waApril 22, akatorwa sero, uye musi waMay 12, akagamuchira kuiswa kwemasero akarapwa eCAR-T. Kubuda kwake kwakabudirira muna Chivabvu 27 kwakaratidza nguva yakakosha murwendo rwake rwekurapwa.
Mumwedzi wake wekutanga kutevera, vashandi vezvokurapa vakaona kufambira mberi kukuru, kunyanya kuderera kweproteinuria. Pakushanya kwakazotevera, mapundu eganda ake akanga apotsa anyangarika, angosara tumapundu padama rake rokurudyi. Nehurombo, proteinuria yake yakanga yagadzirisa zvizere, uye chibodzwa chake cheSLE Disease Activity Index (SLEDAI-2K) chakaratidza chirwere chakapfava, chisingasviki 2.
Apiwa simba nekushanda kweCAR-T cell therapy, Yaoyao zvishoma nezvishoma akabvisa mishonga yake achitariswa nachiremba. Zvinoshamisa ndezvokuti, anga asingashandisi mishonga kwemwedzi inopfuura mina, zvichipupurira kuregererwa kwakasimba kunowanikwa kuburikidza nemaitiro matsva ekurapa aya.
Rwendo rwaYaoyao runosimbisa kugona kwekushandura kweCAR-T kurapwa mukugadzirisa akanyanya autoimmune mamiriro seSLE, achipa tariro uye zvinobatika mhedzisiro uko kurapwa kwechinyakare kungatadza. Chiitiko chake chinoshanda sechiedza chetarisiro kune varwere nemhuri dziri kufamba nematambudziko akafanana, ichiratidza ramangwana rinovimbisa remishonga yemunhu mukutonga kwechirwere che autoimmune.
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