Systemic Lupus Erythematosus (SLE)-03
Muna Nyamavhuvhu 2016, Ms. A ane makore makumi maviri akava netumakwapa tutsvuku pamuviri wake wose uye aigara achipisa muviri, uye akanga aine maplatelet mashoma, mwedzi minomwe asununguka. Mushure mekuongororwa kakawanda muzvipatara zveko, akaonekwa aine systemic lupus erythematosus (SLE) pachipatara chepurovhinzi. Muna October wegore iroro, akatanga kurapwa pachipatara chomunzvimbomo.
“Kwemakore manomwe apfuura, ndaifanira kushanyira chipatara mwedzi nomwedzi kuti ndipiwe mishonga, kuongororwa ropa nguva nenguva, kuongororwa weti, uye kugara ndichipiwa mishonga nemajekiseni, asi chirwere chacho chakaramba chichingoitika, izvo zvairwadza zvikuru,” akadaro Ms. A. Achiedza kurapa chirwere chake, murume wake akamuendesa kuzvipatara zvakawanda, asi kudhura kwacho hakuna kumubatsira. Pakupedzisira, akazoita lupus nephritis uye encephalopathy, uye munaGunyana 2022, akavhiyiwa uropi. Vachinzwa kuti CAR-T therapy inogona kurapa SLE, Ms. A vakatsvaga rubatsiro kubva kuchipatara chedu, uko boka renyanzvi rakaongorora pakarepo mamiriro ake.
Chiremba akatsanangura kuti, "Murwere uyu paakatanga kupiwa mvumo, akanga aine edema yakawanda, proteinuria inokosha, uye masoja ekudzivirira chirwere. Akanga aitwa mishonga yechinyakare yehomoni uye immunosuppressive therapies, pamwe nemaraundi manomwe ekurapwa kwebiology, asi hapana akabudirira. Akatanga lupus. encephalopathy, pulmonary hypertension, pulmonary fibrosis, uye renal biopsy yake yakaratidza kushanda kwe lupus Inofananidzwa nemishonga yemakemikari echinyakare kana monoclonal antibodies, masero eCAR-T anogona kupinda mukati mezvipingamupinyi zvenyama, kuparadzira zvakanyanya mumatishu, uye kuita cytotoxic effect, kunyanya kurwisana neB masero kana masero eplasma mumapundu ematishu asingasviki nemonoclonal antibodies. Pasina ‘mhodzi dzehosha,’ masoja emuviri omurwere anoderera zvishoma nezvishoma, anokwana anodzokera kune zvakajairika, uye zviratidzo zvacho zvishoma nezvishoma zvinopera kana kuti kunyangarika.” Naizvozvo, murwere akabudirira kurapwa neCAR-T.
Amai A vakati, "Iye zvino mavara matsvuku pamuviri wangu apera, uye handichadi mishonga yehomoni kana immunosuppressants. Ndaimbopota ndichiongororwa ropa uye weti, asi ikozvino ndinongoda mwedzi mitanhatu yega yega. Mamiriro angu ose ndeaya. zvakanaka, uye zviratidzo zvese zvakajairika.
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