Systemic Lupus Erythematosus (SLE)-01

Xiaohuan ane makore makumi maviri nemana ave achidzidzira mushonga kuyunivhesiti kwemakore matatu uye anga achirwara ne systemic lupus erythematosus (SLE) kweanoda kusvika makore gumi. "Ndakaonekwa ndine gumi, uye chiremba akati zvaive zvakaoma kurapa, zvekuti ndaingokwanisa kudzora nemishonga," Xiaohuan akadaro achinyemwerera. Mumakore gumi apfuura, aifanira kuenda kunoongororwa mwedzi woga woga uye kunyorerwa mishonga, uye akarapwa mahormone, immunosuppressive therapy, uye biological therapy, asi hapana yakashanda. Akatsungirira kurasikirwa kukuru kwebvudzi, mapundu akawanda, fivha yaidzokororwa, uye kurwadziwa kwakapararira.

Mushure mekuongororwa kwakasiyana-siyana kwekutanga, Xiaohuan akasangana nemaitiro ese ekiriniki eCAR-T kurapwa kweSLE. Chikwata chehunyanzvi chakagadzira chirongwa chekurapa zvine hungwaru zvichienderana nemamiriro ake uye kunyatsogadzirira kuunganidzwa kwesero. Musi waKurume 28, iyo mononuclear cell collection yakatanga. Musi waApril 22, akatanga lymphodepleting chemotherapy. Musi waKubvumbi 28, maseru akapinzwazve. Mamiriyoni makumi maviri eCAR-akagadziridzwa T maseru akapinzwa zvishoma nezvishoma mutsinga yeXiaohuan, yakanangana neiyo lupus B masero, kutanga "chaiyo kurwisa, pwanya iwo imwe neimwe" kurwisa.

Musi waChikumi 4, zuva remakumi matatu nemasere mushure mekunyudzwa, Xiaohuan akadzokera kuchipatara kuti anoteedzerwa. Mhedzisiro yebvunzo yakaratidza kuti zviratidzo zvese zvakakosha zvakadzika kusvika kune zvakajairika. "Ini handichada mishonga yemahormone; zvinoita sekunge hupenyu huchangotanga," Xiaohuan akadaro achifara.