Shawn [Zita Rekupedzisira Risina Kupihwa]----Acute B-lymphocytic Leukemia (B-ALL)

Yakanakisa CAR-T kiriniki kuyedza inoponesa Hong Kong B-YESE murwere.

Shawn, murume ane makore 29 okukura anobva kuHong Kong. Muna March 2017, ane zviratidzo fivha, kuneta uye paleness. Akaonekwa aine acute B-lymphocytic leukemia paPrince of Wales Hospital uye akagamuchira induction chemotherapy. Muna Kubvumbi akapinda mukuregererwa kwakakwana nechemotherapy uye radiotherapy. Uye hapana abnormalities akawanikwa mu CSF correlation report.

Nekudaro, kusvika 19 Kubvumbi 2018, mwongo wake morphology yakaratidza 10% yeprimary nepwere gonorrhoea. Vanachiremba vekuHong Kong vanofunga kuti chemotherapy yakaoma kumuita kuti aregererwe zvakakwana, chete CAR-T ine mukana mukuru wekuzviita. Mushure mekurudziro yavanachiremba uye nekuenzanisa mwero wekubudirira uye kushanda nesimba, Shawn akauya kuLu Daopei Hospital kuChina kuzotora chikamu muyedzo yeCAR-T yekiriniki musi wa23 Kubvumbi 2018.

Iyo yekubvumidzwa bone marrow biopsy bvunzo yakaratidza kuti anga asiri mukuregererwa kwakakwana uye CD19, CD20 yakanaka. Mushure mekubvunzurudzwa kwakasiyana-siyana, vehematologists vedu vanoti atore chikamu muCD19+CD20 CAR-T yekiriniki yekiriniki isati yaiswa mwongo. Mumakesi edu mazana matatu eCAR-T, mwero wakakwana wekuregererwa unotenderedza 90%.

Musi wa25 Kubvumbi, Shawn's T-seli akaunganidzwa akatumirwa kuGMP CAR-T laboratori yemajini engineering. Mushure mekugadziriswa genetically, maT-seli akashandurwa kuita "chimeric antigen receptor (CAR) T-seli". MaCAR mapuroteni anobatsira maT-seli kuona antigen mumasero anonangwa bundu. Mushure mekunge masero eCAR T akura kusvika yakaringana kurapwa, masero eCAR T anopinzwa maari kubvisa bundu masero.

Shawn akagamuchira 1 kosi yechemotherapy musi wa 6 Chivabvu, ari mazuva mashanu pamberi peCAR-T cell infusion. Pana May. Musi wa11 Chivabvu, kuiswa kweCD19 CAR-T masero kwakapihwa se cellular immunotherapy. Mushure memavhiki e4 ekutsigirwa kwekutarisira uye neside effect management, hapana kusakanganiswa kwakawanikwa muCSF correlation report, flow cytometry, bone marrow cell morphology, DNA test uye CAR-T report yakaratidza kuti akawana kuregererwa kwakakwana.

Kuva mukuregererwa kwakakwana ndiyo nzira yakanakisisa yokuti adzokere kuHong Kong nokuda kwenhano inotevera—kuisirwa ropa nemwongo.