Optic Nerve Injury-02

Stem Cell Therapy yeOptic Nerve Injury: Chishamiso Chekudzorera Kuona

Muruzivo rwezvokurapa rwuri kufambira mberi nokukurumidza, zvirwere zvakawanda zvaimboonekwa sezvisingarapiki zvava kuona tariro itsva. Nhasi, tinogovera nyaya inobata-bata nezve mesenchymal stem cell (MSC) kurapwa kwe optic nerve injury, nzira yekurapa inounza tariro itsva yekuona kuvarwere vakawanda.

Nyaya yaVaZhang

VaZhang, vane makore makumi mana nemanomwe ekuberekwa, injiniya akazvipira. Zvisinei, hupenyu hwake hwakachinja zvakanyanya mwedzi mina yapfuura nekuda kwenjodzi yemotokari. Mutsaona iyi, VaZhang vakakuvadzwa zvakanyanya patsinga yavo yekurudyi, zvichikonzera kuderera kwekuona nekukurumidza. Pasinei nekurapwa kwechinyakare nesteroids uye neurotrophic mishonga, chiono chake chakaratidza kuvandudzwa kudiki. Izvi zvakamushungurudza iye nemhuri yake zvikuru.

Pakurudziro yeshamwari, VaZhang vakadzidza nezvemushonga uchangoburwa- mesenchymal stem cell therapy. Mushure mekubvunzurudzwa kwakadzama navanachiremba vane hunyanzvi uye nekunzwisisa zvizere maitirwo ekurapa, VaZhang vakasarudza kuedza nzira itsva iyi.

Iwo stem maseru akatorwa kubva mumbilical cord ropa revazvipiri vane hutano, akaongororwa zvakasimba uye akawedzerwa mutsika kuti ave nemasimba ekugadzirisa uye kugadzirisa. Richishandiswa nejekiseni remukati meoptic nerve sheath, masero aya akaunzwa muziso rekurudyi raVaZhang kuti akurudzire kuvandudzwa kwetsinga yemaziso yakakuvadzwa.

Maitiro ekurapa akaitwa munzvimbo isina hutachiona kuti ave nechokwadi chekuchengetedza uye kunyatsoita padanho rega rega. Muvhiki yekutanga mushure mekuvhiyiwa, VaZhang vakangosangana nekuzvimba zvishoma uye kusagadzikana panzvimbo yejekiseni, pasina zvimwe zviratidzo. Zvisinei, zvinoshamisa, pakupera kwemwedzi wekutanga mushure mekushanda, VaZhang vakatanga kuona chiedza chisina simba uye vaigona kuona chiedza chakajeka. Kuchinja uku kwakaita kuti ave netariro yeramangwana.

Mumwedzi yakatevera, chiono chaVaZhang chakavandudzika zvishoma nezvishoma. Pakazosvika mwedzi wechitatu, aikwanisa kuona mafambiro ezvinhu zvakakura, uye bvunzo dzekuona dzakamutswa (VEP) dzakaratidza kupora kwakanyanya kweoptic nerve conduction function. Pakazosvika mwedzi wechitanhatu, kuona kweziso rake rekurudyi kwakagadzikana kutenderedza 0.15, zvichimugonesa kusiyanisa mafonti akakura uye maumbirwo ari nyore, achiwedzera zvakanyanya hupenyu hwake hwezuva nezuva.

Kupora kwaVaZhang hakungorevi kukunda kwemishonga yemazuva ano chete asiwo chiratidzo chekuedza kwakaungana kwevaongorori vezvokurapa vasingaverengeki nevazvipiri. Mesenchymal stem masero, kuburikidza nekuvanzika kwezvinhu zvakasiyana-siyana zvekukura uye ma cytokines, akafambisa kuvandudzwa uye kushanda kupora kweiyo yakakuvadzwa optic nerve. Iyi nzira yekurapa inoratidza kugona kukuru, ichipa tariro kune varwere vazhinji vakaita saVaZhang.