Tariro Itsva muCancer Kurapa: TILs Therapy Inobuda seInotevera Frontier
Munda we cell therapy urikuenderera mberi nekushanduka, neTIL kurapwa iko zvino kuri kubuda sebudiriro yakakosha mukurapa cancer. Zvisinei netarisiro huru yakanamirwa pakurapa kweCAR-T, kukanganisa kwayo pamamota akasimba, ayo anosanganisira makumi mapfumbamwe muzana egomarara, ane mashoma. Nekudaro, kurapwa kweTIL kwakagadzirira kushandura iyo rondedzero.
Kurapa kweTIL nguva pfupi yadarika kwakatariswa zvakanyanya apo Iovance Biotherapeutics 'Lifileucel yakagamuchira yakakurumidza kubvumidzwa neFDA munaFebruary 16 yekurapa melanoma iyo yafambira mberi zvichitevera PD-1 antibody therapy. Mvumo yaLifileucel inoiratidza seyekutanga kurapa kweTIL kusvika pamusika, ichisaina chikamu chitsva musero therapy yakatarisana nemamota akasimba.
Mugwagwa Wakareba Wekubudirira
Rwendo rweTIL kurapwa runotora makore anopfuura makumi mana. Tumor-Infiltrating Lymphocytes (TILs) iboka rakasiyana-siyana remasero ekudzivirira anowanikwa mukati me tumor microenvironment, kusanganisira T masero, B masero, NK masero, macrophages, uye myeloid-derived suppressor cells. Aya maseru, anowanzo kushomeka muhuwandu uye kuita mukati memamota, anogona kukohwewa, kukwidziridzwa murabhoritari, uye kudzoserwa mumurwere kunanga nekuparadza maseru egomarara.
Kusiyana nemasero eCAR-T, maTIL anotorwa zvakananga kubva mubundu, achivabvumira kuziva huwandu hwakakura hwema tumor antigens uye kupa zvirinani kupinza uye kuchengetedza profiles. Iyi nzira yakaratidza vimbiso, kunyanya mukurapa mabundu akasimba uko CAR-T yakatamburira kugadzirisa.
Kupedza Matambudziko
Lifileucel yakaratidza zvinokatyamadza mhedzisiro yekiriniki, ichipa tariro kune varwere vemelanoma vane mashoma ekurapa sarudzo. MuC-144-01 kuyedzwa kwekiriniki, kurapa kwakawana mwero wekupindura we31%, ne42% yevarwere vakawana mhinduro dzinotora makore maviri. Pasinei nekubudirira uku, nzira yekugamuchirwa kwakapararira inotarisana nezvipingamupinyi zvakakura.
Zvinetso zveMaindasitiri neKutengesera
Imwe yematambudziko ekutanga ndeye yakasarudzika hunhu hweTIL kugadzirwa, iyo inoda yakareba uye yakaoma kugadzira maitiro. Nepo Iovance yakadzikisa nguva yekugadzira kusvika kumazuva angangoita makumi maviri nemaviri, kumwe kukurumidza kunodiwa kusangana nezvinodiwa nevarwere nekukurumidza. Kambani ine chinangwa chekupfupisa nguva iyi kusvika kumazuva gumi nematanhatu kuburikidza nekufambira mberi.
Kutengeserana kunopawo zvipingamupinyi. Mutengo wepamusoro wekurapwa kwemunhu — pari zvino mutengo wemadhora zviuru mazana mashanu nemakumi mashanu neshanu kuLifileucel, nemari yekuwedzera yekurapa — inomisa kutorwa kwekutanga kumusika weUS. Kuti uwane kusvika pasi rose uye kubudirira kwehupfumi, makambani anofanirwa kufambisa kugadzirwa uye kuderedza mitengo.
Kurerutsa maitiro ekurapa kuwedzera ruzivo rwemurwere ndechimwe chinhu chakakosha. Kurapa kweTIL kunosanganisira matanho akati wandei, anosanganisira bundu tishu kuunganidzwa, kuwedzera masero, uye lymphodepletion, zvese zvinoda nyanzvi dzekurapa nevashandi. Kuvaka network yakakura uye inoshanda yekurapa kwakakosha pakubudirira kwekutengeserana.
Ramangwana Revimbiso
Tichitarisa kumberi, kuwedzera kweTIL kurapwa kune mamwe mamota akasimba kunoramba kuri chinangwa chakakosha. Nepo tsvakiridzo yazvino yakatarisa zvakanyanya pa melanoma, kuedza kuri kuenderera mberi kwekuongorora kushanda kwayo mune mamwe magomarara akadai seasiri diki kenza yemapapu. Kunzwisisa nuances yeTIL kurapwa, kusanganisira kuziva kuti ndeapi masero eT anonyanya kushanda uye kugadzira mishonga yekubatanidza, ichave yakakosha.
Kubatanidza marapirwo, kubatanidza maTIL nemishonga yakajairika senge chemotherapy, radiation, immunotherapies, uye majekiseni, anoratidza kugona mukusimudzira mhedzisiro yekurapa uye kuderedza mhedzisiro. Makambani akaita seIovance ari kutoongorora masanganiswa nePD-1 inhibitors, nechinangwa chekuvandudza kushanda kweTIL uye mazinga ekupindura kwevarwere.
Sezvo Lifileucel inovhura nzira yeTIL kurapwa, munda wesero kurapa unomira pamucheto wenguva yekushandura mukurapwa kwakasimba bundu. Iko kuedza kwakabatana uye hunyanzvi kubva kumakambani emishonga ndiwo anozoratidza kuti ndiani anotungamira iyi muganhu mutsva. Tariro yakabatidzwa neTIL therapy inovimbisa kukwevera zviwanikwa uye kutarisisa, kutyaira kufambira mberi uye kupa tariro nyowani kuvarwere pasi rese.