Chipatara cheLu Daopei's Low-Dose CD19 CAR-T Therapy Inoratidza Mibairo Inovimbisa muB-ALL Varwere

Muchidzidzo chepasi pasi chakaitwa paLu Daopei Hospital, vatsvakurudzi vakashuma kufambira mberi kukuru mukurapa refractory kana kudzokazve B acute lymphoblastic leukemia (B-ALL) vachishandisa yakaderera-dose CD19-inotungamirwa CAR-T cell therapy. Chidzidzo ichi, icho chaisanganisira varwere makumi mashanu nemumwe, chakaratidza kuti iyi nzira yekuvandudza haina kungowana yakakwirira yakakwana yekuregererwa (CR) mazinga asi zvakare yakachengetedza yakanaka kuchengetedza chimiro.

Boka rekutsvagisa, rinotungamirwa naDr. C. Tong kubva kuDhipatimendi reHematology uye Dr. AH Chang kubva kuClinical Translational Research Center paTongji University School of Medicine, yakaongorora mhedzisiro yekupa muyero wakaderera wemasero eCAR-T-anenge 1. × 10 ^ 5 / kg-ichienzaniswa neyakajairwa madosi epamusoro. Iyi nzira yakanangana nekuenzanisa kurapa kwakanaka nekudzikisira kwezvakanyanya mhedzisiro, kunyanya cytokine release syndrome (CRS).

Zvigumisiro zvechidzidzo chacho zvaikurudzira. Pakati pe42 refractory / relapsed B-ALL varwere, 36 vakawana CR kana CR ine isina kukwana kuverenga kupora (CRi), nepo varwere vapfumbamwe vane chirwere chidiki chekusara (MRD) vakasvika MRD negativity. Uyezve, varwere vazhinji vaingosangana neCRS yakapfava kusvika pakati nepakati, iine nyaya dzakakomba dzichigadziriswa nemazano ekutanga ekupindira.

Dr. Tong akasimbisa kukosha kwechidzidzo ichi, achiti, "Zvigumisiro zvinoratidza kuti kuderedza-dose CD19 CAR-T cell therapy, inoteverwa neallogeneic hematopoietic stem cell transplantation (allo-HCT), inopa nzira yekurapa inoshanda zvikuru kune varwere vane Dzimwe nzira dzisina kukwana. Kurapa uku hakungopi mwero wekupindura kwakanyanya asiwo kunoderedza zvakanyanya njodzi yemhedzisiro yakaipa.

Kubudirira kwechidzidzo ichi kunosimbisa kugona kweakagadzirirwa CAR-T cell therapies mukurapa yakaoma hematological malignancies. Lu Daopei Hospital, ine mukurumbira nebasa rekupayona mucellular immunotherapy, inoramba ichitungamira mukupa marapirwo ekurapa kune varwere vane dambudziko rehematologic.

Sezvo chidzidzo ichi chichienderera mberi, timu yekutsvagisa ine tarisiro yekuwedzera kunatsa dosi uye maprotocol ekuwedzera mhedzisiro yemurwere. Zvakawanikwa kubva muongororo iyi zvakatsikiswa mujenariLeukemiauye kupa tariro yetariro yevarwere veB-ALL pasi rose.