Innovative CAR-T Cell Therapies Shandura Kurapa kweB Cell Malignancies
Muongororo ichangobva kuitika yakabudiswa mu Journal of the National Cancer Center, nyanzvi kubva kuLu Daopei Hospital, inotungamirirwa naDr. Peihua Lu, pamwe chete nevabatsiri veThe University of Texas MD Anderson Cancer Center, vakajekesa kufambira mberi kwekupedzisira muCAR-T. masero ekurapa ekurapa B-cell malignancies. Ongororo iyi yakazara inokurukura nzira dzakati wandei dzehunyanzvi, kusanganisira shanduko yeCAR-T cell dhizaini uye kubatanidzwa kweadoptive cell therapies, kuvandudza kushanda uye kuchengetedzeka kwemishonga yezvirwere zvakaita senon-Hodgkin's lymphoma (NHL) uye acute lymphoblastic leukemia (ZVESE). )
B-cell malignancies inounza matambudziko makuru nekuda kwemaitiro avo ekudzoka zvakare uye kukudziridza kurambana nemaitiro ekurapa. Kuunzwa kwechimeric antigen receptor (CAR) T masero akashandura mamiriro ekurapa, achipa tariro nyowani kuvarwere vakatarisana neaya macancer ane hutsinye. Chidzidzo ichi chinotaridza kuti maseru eCAR T anogona kugadzirwa sei neakawanda mazera ekugadzira, achibatanidza maficha epamberi senge bispecific receptors uye costimulatory domains, kuti anyatso kunanga bundu maseru uye kuderedza mukana wekudzoka zvakare.
Lu Daopei Hospital yanga iri pamberi pekutsvagisa masero eCAR-T uye kiriniki application, ichiratidza budiriro inoshamisa mukupenengura kuregererwa kwenguva refu. Kuita kwechipatara ichi mubasa rekutanga kunosimbisa kuzvipira kwacho mukusimudzira kurapwa kwegomarara uye kupa rubatsiro rwechizvino-zvino. Ongororo iyi zvakare inoongorora kugona kwekubatanidza marapirwo eCAR-T nemamwe marapirwo, akadai seimmunotherapy uye anonangwa marapirwo, kukunda nzira dzekupokana nekuvandudza mhedzisiro yevarwere.
Chinyorwa ichi chiratidzo chekushanda pamwe chete kwevaongorori vepasi rese nevarapi mukusundidzira miganhu yekurapa gomarara. Zvakawanikwa zvinopa tarisiro yeramangwana rechokwadi oncology, uko kurapwa kwemunhu uye kwehunyanzvi kunogona kushandura hupenyu hwevarwere vari kurwisa B cell malignancies. Mipiro yeLu Daopei Hospital kundima iyi chiratidzo chetariro, inofambisa kuvandudzwa kweakachengeteka uye anoshanda zvakanyanya marapirwo egomarara.