Kuwedzera Antitumor Kubudirira kwe4-1BB-Yakavakirwa CD19 CAR-T Masero muKurapa B-ALL

Muchidzidzo chekiriniki chakakosha chakaitwa neLu Daopei Hospital neLu Daopei Institute of Hematology, vaongorori vakawana kuti 4-1BB-based CD19 CAR-T masero anopa inovimbisa imwe nzira kune echinyakare maCD28-based CAR-T masero ekurapa akadzokera shure kana kuramba. B cell acute lymphoblastic leukemia (r/r B-ALL). Ichi chidzidzo, chinosanganisira kwakasimba pre-kiriniki uye kuongororwa kwekiriniki kuferefeta, kwakaratidza kuti 4-1BB CAR-T masero haangopi yakakwira antitumor efficacy asiwo anoratidza kutsungirira kwenguva refu muvarwere vachienzaniswa neavo CD28.

Chipatara cheLu Daopei Chikwata chekutsvagisa chakanyatso enzanisa mashandiro emhando mbiri idzi dzeCAR-T. Vakaona kuti, pasi pemaitiro akafanana ekugadzira, 4-1BB CAR-T masero aive neakanyanya antitumor mhedzisiro pamiyero yakaderera uye akakonzera mashoma akanyanya kuipa zviitiko kupfuura CD28 CAR-T masero. Mhedzisiro yechidzidzo ichi inoratidza kuti 4-1BB-based CAR-T therapy inogona kupa nzira inoshanda uye yakachengeteka yekurapa kune varwere vane r/r B-ALL.

Izvi zvakawanikwa zvinosimbisa kuzvipira kwechipatara cheLu Daopei mukusimudzira hematology uye immunotherapy, zvichipa tariro kune varwere vasina kupindura kurapwa kwakajairika. Ongororo iyi, iyo yakatevera mipimo yakaomesesa yetsika uye yakagamuchira mvumo kubva kuLu Daopei Hospital Ethics Committee, inosimbisa basa rechipatara mukutungamirira tsvakiridzo itsva muCAR-T cell therapies.

Nekubudirira uku, iyo Lu Daopei Institute of Hematology inoenderera mberi nekupayona mitsva mukutsvaga kwekurapa, ichipa nzira dzekurapa dzepamusoro uye nekuvandudza mhedzisiro yevarwere. Kufambira mberi uku chiratidzo chekuzvipira uye hunyanzvi hwezvikwata zvekurapa nekutsvaga zvechipatara cheLu Daopei.