Bioocus Inosimudzira Muganho muKurapa Pediatric Acute Lymphoblastic Leukemia
Chiitiko chakakosha mumunda weCAR-T therapy, yakaratidzwa nekudhindwa kwechangobva kubudiswa kwekuongorora kwepasi kwakatungamirirwa naDkt Chunrong Tong paLu Daopei Hospital. Chidzidzo ichi, chakanzi "Chiitiko uye Zvinetso zveSecond-Generation CD19 CAR-T Cell Therapy muPediatric Acute Lymphoblastic Leukemia," inopa ongororo yakazara yekushanda uye kuchengetedzeka kwechizvarwa chechipiri CD19 CAR-T cell therapy mukurapa vana acute lymphoblastic leukemia. (VOSE).
Tsvagiridzo iyi inosimbisa kugona kwehunyanzvi kweBiocus's CAR-T chigadzirwa mukugadzirisa imwe yeakanyanya kunetsa mamiriro ehematological muvana. Chidzidzo ichi chinotsanangura nezvemhedzisiro yekiriniki inocherechedzwa muvarwere vakawana kurapwa uku, zvichiratidza vimbiso yekuregererwa. Nekudaro, inotaridzawo matambudziko akanyanya, kunyanya manejimendi akanyanya cytokine release syndrome (CRS) uye neurotoxicity, iyo inoramba iri nzvimbo dzakakosha dzekutarisa kuvandudza kuchengetedzwa kwevarwere.
Bioocus's CAR-T therapy, inoratidzwa muchidzidzo ichi, inosimudzira chizvarwa chechipiri dhizaini inosimudzira T-cell chiitiko kurwisa cancer maseru anoratidza CD19 antigen. Iyi nzira yakakosha mukukunda nzira dzekupokana dzinowanzo sangana mukudzokororwa kana kuramba kwevana ALL kesi. Mibairo yakapihwa mubhuku rino haingoratidzi kugona kwekurapa kweBioocus's CAR-T chigadzirwa asi zvakare inosimbisa kukosha kwekuenderera mberi kwehunyanzvi uye tsvakiridzo yekiriniki yekukwenenzvera marapirwo aya zvakare.
Tsvagiridzo yaDr. Tong inopa ruzivo rwakakosha mukushandiswa kweCAR-T marapirwo uye inopindirana nechinangwa cheBioocus kusimudzira kurapwa kwegomarara kuburikidza nekucheka-kumucheto biotechnological mhinduro. Semutungamiri wepasi rose mukusimudzirwa kweCAR-T, Bioocus anoramba akazvipira kusundira miganhu yezvinogoneka mukurapwa kwegomarara, nechinangwa chekupedzisira chekuvandudza mhedzisiro yemurwere uye hupenyu hwehupenyu.
Sezvo Bioocus ichiri kuramba ichidyidzana nemasangano ekurapa anotungamira seLu Daopei Hospital, tinoramba takazvipira kugadzirisa zvimhingamipinyi zvakaonekwa muchidzidzo ichi uye kunatsa zvigadzirwa zvedu zveCAR-T kuti zviwedzere kuchengetedzeka uye kushanda nesimba. Kuzvipira kwedu kune hunyanzvi uye hutsva hunovimbisa kuti isu takanyatso kutungamira remangwana rekurapa cancer.