Ko Maserura Therapies Ndiwo Remangwana reAutoimmune Disease?
Kurapa kwechimurenga kwegomarara kunogona zvakare kurapa nekugadzirisa zvakare immune system kuti ipe kuregererwa kwenguva refu kana kurapa zvimwe zvirwere zve autoimmune.
Chimeric antigen receptor (CAR) T-cell therapy yakapa nzira itsva yekurapa hematologic cancer kubvira 2017, asi pane zviratidzo zvekutanga zvekuti ma cellular immunotherapies anogona kudzoserwa kune B-cell mediated autoimmune zvirwere.
MunaGunyana wegore rapfuura, vaongorori vekuGermany vakashuma kuti varwere vashanu vane refractory systemic lupus erythematosus (SLE) vakarapwa neCAR T-cell therapy vese vakawana kuregererwa pasina zvinodhaka. Panguva yekuburitswa, hapana murwere akange adzokazve kusvika kumwedzi gumi nenomwe mushure mekurapwa. Vanyori vakatsanangura seroconversion yeantinuclear antibodies muvarwere vaviri vane nguva refu yekutevera, "zvichiratidza kuti kubviswa kweautoimmune B-cell clones kunogona kutungamira mukugadziriswa kwakapararira kweautoimmunity," vanotsvaga vanonyora.
Mune imwe nyaya yakabudiswa muna June, vatsvakurudzi vakashandisa CD-19 yakanangidzirwa masero eCAR-T kurapa murume ane makore makumi mana nerimwe ekuberekwa ane refractory antisynthetase syndrome ine myositis inopfuurira uye chirwere chemapapu chepakati. Mwedzi mitanhatu mushure mekurapa, pakanga pasina zviratidzo zvemyositis paMRI uye chifuva CT scan yakaratidza kuzara kwakazara kwealveolitis.
Kubva ipapo, makambani maviri ebiotechnology - Cabaletta Bio muPhiladelphia neKyverna Therapeutics muEmeryville, California - akatopihwa mazita ekukurumidza kubva kuUS Food and Drug Administration yeCAR T-cell therapy yeSLE uye lupus nephritis. Bristol-Myers Squibb iri kuitawo chikamu chekutanga muyedzo muvarwere vane yakaoma, inopikisa SLE. Makambani akati wandei ebiotechnology uye zvipatara muChina zviri kuitawo miedzo yekiriniki yeSLE. Asi iyi ingori muromo weiyo iceberg nezve cellular marapirwo echirwere che autoimmune, akadaro Max Konig, MD, PhD, anobatsira purofesa wezvemishonga muchikamu cherheumatology paJohns Hopkins University Chikoro cheMishonga muBaltimore.
"Inguva inofadza zvikuru. Hazvina kumboitika munhoroondo ye autoimmunity, "akadaro.
A "Reboot" yeImmune System
B-sero rakanangana nekurapa kwave kuripo kubva kutanga kwa2000 nemishonga yakaita serituximab, monoclonal antibody mishonga inonangana neCD20, antigen inoratidzwa pamusoro pemaseru B. Masero eCAR T aripo parizvino anonangidzira imwe nzvimbo antigen, CD19, uye kurapa kune simba zvakanyanya. Ose ari maviri anoshanda pakupedza masero eB muropa, asi aya akagadzirwa eCD19-anotariswa T masero anogona kusvika B masero akagara mumatissue nenzira isingakwanise kurapa masoja ekudzivirira chirwere, Konig akatsanangura.