Myasthenia gravis-01

Zhang Wei's Myasthenia Gravis Kurapwa Nyaya

Zhang Wei, ane makore makumi matatu nemaviri ekugadzira software, akatanga kuona zviratidzo zve myasthenia gravis (MG) makore maviri apfuura. Pakutanga, aive neptosis (kudonha kwemaziso) uye kusaona zvakanaka, asi zviratidzo zvake zvakawedzera kuipa nekufamba kwenguva, zvichikonzera kushaya simba kwetsandanyama kwakakanganisa zvakanyanya basa rake uye hupenyu hwezuva nezuva. Pasinei nokurapwa kwakasiyana-siyana, kubatanidza mishonga inorwisa cholinesterase, mishonga inodzivirira muviri, uye intravenous immunoglobulin, zviratidzo zvake zvakaramba zviripo uye zvaiwanzodzoka.

Nekurapa kwechivanhu kuchiratidza kusashanda, vanachiremba vakakurudzira kuti Zhang Wei aedze nzira itsva yekurapa: CAR-T cell therapy. Iyi innovative therapy inoshandisa genetic engineering kushandura masero eT emurwere, achivagonesa kunanga uye kubvisa masero asina kujairika ane chekuita nechirwere.

Mushure mekunyatsoongorora, Zhang Wei akaonekwa akakodzera kurapwa. Vanachiremba vakatanga vabvisa masero eT kubva pamuviri wake ndokuachinja magene uye ndokuawedzera murabhoritari. Zhang Wei akabva aitwa conditioning chemotherapy kuti aderedze huwandu hwemalymphocyte aripo mumuviri wake, achigadzirira kuiswa kwemaseru eCAR-T. Pakupedzisira, masero eCAR-T akagadziridzwa akadzoserwa mumuviri waZhang Wei.

Munguva yekutanga yekurapa, Zhang Wei akawana kuneta kwenguva pfupi, asi mavhiki maviri gare gare, zviratidzo zvake zvakatanga kuwedzera zvakanyanya. Iyo ptosis uye chiono chakasvibiswa zvakaderedzwa zvakanyanya, uye simba rake rakadzoka zvishoma nezvishoma. Mwedzi mumwe gare gare, kushanda kwake zvakanaka kwakavandudzika, uye aigona kutangazve mabasa emazuva ose. Mwedzi mitatu mushure mekurapwa, zviratidzo zvaZhang Wei zvakange zvapera zvachose, uye akange asisade mishonga yapfuura. Ongororo dzekutevera dzakaratidza kuti immune system yake yaive muchimiro chakanaka, isina mhedzisiro yakaoma kana zviratidzo zvechirwere chekudzoka.

Kuburikidza neCAR-T cell therapy, Zhang Wei's myasthenia gravis yakadzorwa zvakanyanya, ichiwedzera zvakanyanya hupenyu hwake uye kugona basa. Kurapa uku kunopa tariro itsva kune vakawanda myasthenia gravis varwere.