Multiple Myeloma(MM)-02

Murwere wekuItaly Anotsvaka Kurapwa uye Anorapwa Multiple Myeloma neCAR-T Therapy

Cinty, mukadzi ane makore makumi matanhatu nematanhatu, akaonekwa aine lambda light chain multiple myeloma, ISS stage I, muItaly muna Gumiguru 2018. Mushure mekugamuchira 4 cycles yeVTD regimen chemotherapy, akaita kuputsika muchikamu chechitatu che clavicle uye. peripheral neuropathy. Kutsvaga kurapwa kunoshanda, akaita maviri autologous stem cell transplants muna Chivabvu 2019 naNovember 2019, achiwana kuregererwa kwakakwana, uye akachengetwa pamuromo lenalidomide.

Nekudaro, muna Nyamavhuvhu 2020, yekutevera PET / CT scan yakaratidza kuparadzwa kutsva kwebhonzo uye nekukurumidza kuwedzera kweserum yemahara macheni. Bone marrow biopsy yakaratidza kufambira mberi kwechirwere, uye kuongororwa kweFISH kwakaratidza hutsva hwe cytogenetic abnormality: t (11; 14). Mushure me4 kutenderera kweDVD regimen chemotherapy kutanga munaGunyana 2020, chirwere chake chakanga chisingadzoreki uye chakaenderera mberi. Pasinei nekuchinja kumitambo ye3 yePCd regimen, kurwadziwa kwepfupa kwakaramba kuchienderera mberi uye maviri maviri ezasi edema akawedzera. Mushure mekunge apedza marapirwo mazhinji anozivikanwa pasi rose uye akaiswa maviri autologous stem cell transplants, akatanga kuramba mishonga yakawanda.

Paakadzidza nezve kushanda kwakakosha kwechirongwa cheCAR-T chekiriniki paLudaopei Hospital kuburikidza neruzivo rwepamhepo, akanyorera vhiza uye akasvika kuChina munaKurume 2021. Mushure memwedzi wekuvharirwa, akaendeswa kuYanda Ludaopei Hospital musi wa22 Kubvumbi. 2021. Kutevera nhevedzano yebvunzo uye kuongororwa kwechirwere, akagamuchira infusion yeBCMA CAR-T masero mushure meFC chemotherapy preconditioning muna Chivabvu wegore rimwe chetero. Mushure mekuisirwa, zviratidzo zvake zvakakosha zvaive zvakatsiga, uye haana kusangana nemhedzisiro yakakosha kunze kwefivha yakaderera. Edema yake yepasi pemakumbo maviri yakadzikira zvishoma nezvishoma, uye akafara kuona hutano hwake hwese huri nani.

Mwedzi mumwe mushure meCAR-T infusion, Cinty's test results yakaratidza: 24-awa urine protein quantification pa 50 mg / zuva, yakaderedzwa zvakanyanya kubva kumazinga ekugamuchira; serum isina chiedza cheni: FLC-κ pa 4.58 mg / L uye FLC-λ pa 0.61 mg / L; uye kuongororwa kwemwongo wemapfupa hakuna kuratidza masero eplasma anokosha. Akaongororwa nekiriniki seari mukuregererwa kwakakwana (CR).

Parizvino, mwedzi misere adzokera kuItaly, marwadzo emusana aCinty uye edema yemakumbo nemakumbo maviri zvakanyangarika zvachose, uye ane utano hwakanaka. Kubva kuzviuru zvemamaira kure, Cinty akataura kutenda kwake kwechokwadi kuchikwata chiri paYanda Ludaopei Hospital uye Director Zhang Xian.

Aya makiriniki maviri emakiriniki kubva kuLudaopei Hospital anoratidza kuti kunyangwe varwere vane yakaderera kana vasina BCMA kutaura mune akawanda myeloma vanogona kuita zvakanaka neBCMA CAR-T cell therapy. Izvi zvinomiririra kubudirira mukurapa kweCAR-T kune akawanda myeloma, kuunza tariro itsva kune varwere vane advanced plasma cell disorders uye multiple myeloma.