Multi-line Resistant Diffuse Yakakura B-cell Lymphoma (DLBCL)

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Kuongororwa:Multi-line Resistant Diffuse Yakakura B-cell Lymphoma (DLBCL)

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VaX, murwere wechirume, akaunzwa nemulti-line resistant diffuse hombe B-cell lymphoma (DLBCL), mamiriro akaoma anoratidzirwa nekuramba kwebundu kumitsetse yakawanda yekurapa. Pakuongororwa kwekutanga, Mr. X vakanyunyuta nezvekurwadziwa kukuru kwepamuviri, zvichiita kuti kuwedzere kuongororwa.

Zvidzidzo zvekufungidzira, kusanganisira Mufananidzo 1, zvakaratidza huwandu hukuru mudumbu redumbu, zvichiratidza kubatanidzwa kwechirwere. Kuvapo kwevanhu vakawanda kudaro hakuna kungokonzera kusagadzikana mudumbu raVaX chete asiwo kwakaita kuti vazvidye mwoyo pamusoro pokufambira mberi uye utsinye hwelymphoma yavo.

Tichifunga nezvekubudirira kushoma kwemitsara yekurapa kwekare uye kudiwa kwekukurumidzira kwekupindira kunobudirira, Mr. X vakanyoreswa muchirongwa chekliniki cheCD19 + 22 CAR-T cell therapy. Mushure mekuita matanho anodiwa ekugadzirira, kusanganisira pretreatment, Mr. X vakagamuchira infusion yeCD19 + 22 CAR-T masero.

Zvinoshamisa, Mufananidzo 2, wakatorwa mwedzi mitatu mushure mekudzoka kuvharwa kweCD19 + 22 CAR-T masero, yakaratidza kunyangarika kwakakwana kwemuviri wedumbu. Iyi inoshamisa mhinduro yekurapwa yakaratidza mhedzisiro yakabudirira, neiyo lymphoma yakabviswa zvinobudirira.

Murwendo rwavo rwose rwokurapa, Mr. X vakagamuchira kutarisirwa kwakakwana uye kutsigirwa kubva kuboka rezvokurapa. Izvi zvaisanganisira kutarisisa mamiriro ake ezvinhu, kutonga kwemishonga ine chekuita nemishonga, uye kutsigirwa mupfungwa kumubatsira kutsungirira matambudziko ekurwisa kenza.

Pamusoro pezvo, kunze kwekutarisirwa kwekurapa, takapa Mr. X nerubatsiro rwesevhisi kuti ave nechokwadi chekugara zvakanaka kwake panguva yekurapwa kwake. Izvi zvaisanganisira kumurongera pokugara pakanaka, kumupa zvokudya zvinovaka muviri zvinoenderana nezvaanoda kudya, kuronga chokufambisa panguva yaaizogadzwa uye zvinodiwa pakufamba, uye kumutsigira mupfungwa kuti iye nemhuri yake vazvibatsire kufamba munguva iyi yakaoma.

Mhosva yaVa X inoratidzira mikana yezvitsva zvekurapa seCAR-T cell therapy mukukunda mitsara yakawanda inopikisa DLBCL. Inosimbisa kukosha kwekuenderera mberi nekutsvakurudza uye kubudirira mumunda we oncology kupa tariro uye nzira dzekurapa dzinoshanda kune varwere vanotarisana nekenza yakaoma-kurapa seDLBCL.