Junaid----Acute B-lymphocytic Leukemia (B-ALL)

CAR-T yekiriniki yekuyedza bhiriji mwongo transplantation inoita refractory B-ALL murwere chirwere pasina paLu Daopei Hospital.

Makore mashanu apfuura, Junaid aive mudzidzi paPakistan Medical University, azere nezvishuwo zvekuva chiremba. Asi muna Chivabvu 2014, akaonekwa aine acute B-lymphocytic leukemia uye aifanira kusiya zvidzidzo zvake.

Akarapwa munzvimbo ino kweanopfuura makore maviri. Muna Ndira 2018, akagadzira systemic bhonzo kurwadziwa zvakare uye ongororo yemwongo yakaratidza kuti akange adzoka zvakare. Pashure pekosi yechipiri yechemotherapy pachipatara chomunzvimbomo, akanga asingakwanisi kuwana kuregererwa uye hosha yakanga yafambira mberi. Kuburikidza nekutsvaga padandemutande uye kurudziro yevamwe varwere, vakasarudza kuuya kuchipatara cheLu Daopei kuchipatara chepamusoro cheCART uye BMT.

Musi wa26 Kurume 2018, Junaid nemhuri yake vakauya kuChina uye vakapinzwa mudhipatimendi guru rehematology reLu Daopei Hospital. Dr Peggy Lu naDr Junfang Yang vakaita ongororo yakazara yeJunaid. Mishumo yakaratidza kuti kuputika kwebhonzo kwakange kwakakwira kusvika 69% uye aive nepulmonary fungal infections. Mushure mekunyatsorapwa, murwere akanga ari mumamiriro ezvinhu akagadzikana. Musi wa24 Kubvumbi 2018, Junaid akapinzwazve aine maviri CD19 & CD22 CAR-T masero. Pashure pemavhiki maviri, kuputika kwemasero emapfupa akanga ava 0. Nyemwerero dzakadzokera kumhuri yaJunaid. Junaid aifanira kuita BMT kuti asave nechirwere.

Musi wa25 Chikumi 2018, Dr Yue Lu, director wedhipatimendi reBMT, uye timu yaDr Fang Xu yezvechiremba vakaitira mwana weBMT yeJunaid. Anopa Junaid munin'ina wake. musi wa 6 Chikunguru, donor peripheral stem cell yakadzoserwa muJunaid, mushure memazuva gumi nemanomwe kuisirwa masero machena eropa kwakapedzwa uye akabva abuda muwadhi yekuyerera. Mushure memazuva makumi maviri nemana, mhando yemwongo wemapfupa ake inoenderana zvachose nemhando yemwongo weanopa. Kuongororwa kweiyo pfupa residual report haina kunaka, pasina kutapurirana-kwakanangana nekutanga matambudziko. Pana 6 Nyamavhuvhu 2018, Junaid akaburitswa muchipatara ndokutanga kutevera varwere.

Sangano reropa reChinese itsigiro yakasimba yemurwere Junaid is RH negative blood type, inova rudzi rweropa rusingawanikwe. Akagamuchira "Lang Fang rare blood type mubatanidzwa" kupa ropa mahara kwenguva dzakawanda panguva yekurapwa kwake. Hazvimboita sekunge kushomeka kwekuisirwa ropa kwaari, Junaid nemhuri yake vanotenda zvikuru nzvimbo yepasirese yekuitira Junaid zvese izvi. Zvichakadaro, vashandi vepainternational centre vakaperekedza Junaid nemhuri yake kubva pavakasvika kusvika zvino, vakavapa tsigiro youpenyu hwose uye vakabatsira mhuri yacho kukunda chipingamupinyi chomutauro.

CAR-T kiriniki yekuedza mabhiriji BMT kugadzira chimwe chishamiso. Dhipatimendi reBMT reLu Daopei Hospital ndiyo imwe yenzvimbo dzinoshanda dzeBMT pasi rese. Junaid ndiye wechipiri akadzoka zvakare uye akarevera acute B-lymphocytic leukemia murwere kubva kuPakistan kuti agamuchire CAR-T Bridge BMT kurapwa. Kubuda kwaJunaid muchipatara kunoratidza zvakare kuzivikanwa pasi rose kwehunyanzvi hwepamusoro hwechipatara chedu cheCAR-T bridge transplantation.