Diffuse Huru B-cell Lymphoma (DLBCL)

Murwere, mukadzi akatsiga ave kuda kusvitsa makore 80, akashinga akatarisana nekuongororwa kweDiffuse Large B-cell Lymphoma (DLBCL), achiratidza ushingi hunoshamisa muhondo yake yekurwisa rudzi urwu rwegomarara.

Pasinei nokukwegura kwake, akaramba akatsunga kukunda matambudziko aikonzerwa neurwere hwake. Zvisinei, mukati memwedzi mitanhatu mushure mekunge awana kuregererwa nekurapa kwekutanga, akadzokera shure, zvichisimbisa hukasha hwechirwere chake. Kunyangwe akaedza kakawanda kurapwa kwemutsara wechipiri uye wechitatu, gomarara rake rakaratidza kuramba, zvichiunza dambudziko rakakura kuchikwata chake chekurapa.

Vachiona kurumidziro yemamiriro ake ezvinhu, boka rezvokurapa rakatanga kutsvaka kuongorora mamwe marapirwo angaitwa. Murwere akanyoreswa muyedzo yekiriniki yekuongorora CD19 + 22 CAR-T cell therapy, nzira yekucheka-cheka inoshandisa maT cell akagadzirwa nemajini kunongedza masero egomarara anoratidza chaiwo maantigen.

Migumisiro yacho yakanga isiri chinhu chisina kujairika. Mwedzi mumwe chete uchitevera kuiswa kweCD19+22 CAR-T masero, murwere akawana kuregererwa kwakakwana. Mhedzisiro iyi inokatyamadza haina kungomisa kufambira mberi kwechirwere chake asi zvakare yakatungamira mukupedzwa kwakabudirira kwemasero egomarara, zvichiratidza nguva yakakosha murwendo rwake rwekurapa.

Mukati memuitiro wacho wakaoma, boka rezvokurapa rakapa tsigiro isingazununguki nokutarisira kumurwere. Kubva pakunyatsotarisisa mhinduro yake pakurapa kusvika pakugadzirisa chero zviitiko zvakashata, vakave nechokwadi chekuti kugara zvakanaka kwake kwakaramba kuri pamberi pekutanga.

Achifunga nezvezvakaitika kwaari, murwere wacho akaratidza kuonga kukuru nokuda kwokutarisirwa kwetsitsi kwaakaitwa. "Kuzvipira uye hunyanzvi hwechikwata changu chekurapa chaive chakasarudzika," akadaro. "Maitiro avo ega ega ekurapa akandipa tariro pandainyanya kuda."

Mhedzisiro yakabudirira yeCD19+22 CAR-T cell therapy mukuwana kuregererwa kwakakwana inosimbisa kugona kwayo senzira inovimbisa yekurapa kune vanoramba DLBCL varwere. Mhosva iyi inoshanda seuchapupu kusimba rehunyanzvi hwekurapa uye mushonga wakasarudzika mukugadzirisa zvirwere zvegomarara, kunyanya muvarwere vakura semukadzi akashinga uyu.

Pamberi & 1 mwedzi mushure mekuiswa