Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Makorokoto! Murwere anobva kuNorway, Bjørn Simensen, ane makore maviri ekuregererwa kwakasimba.

Murume ane makore makumi matanhatu nemanomwe Bjørn Simensen akaendeswa kuchipatara munaGunyana 2017 aine zvichemo zvekukosora uye kurwadziwa muchipfuva. Munguva yekushanda kwake, akawanikwa aine akawanda myeloma (IgG lambda) ISS-II. Murwere akagamuchira 4 maitiro e bortezomib, lenalidomide uye dexamethasone chemotherapy. Post 4 cycles yake M protein yaive isingasviki 1g/l. Murwere akabva abuda lenalidomide kuchengetedza (10mg qdx3 mavhiki pamwedzi m) yaakaenderera mberi kwemakore anotevera 2. Akaramba asina chirwere kusvika muzhizha ra2021 apo panguva yekuongorora kuregererwa akawanikwa aine M protein (5g/l). Lenalidomide yakamiswa uye yakatangwa pacarfilzomib uye daratumumab chemotherapy kubva muna Gumiguru kusvika Zvita 2021. Zvisinei, chemotherapy yakanga isingashande uye post-chemo BM MRD yakanga yakanaka.

Mr Bjørn Simensen vakatanga kuonekwa paLu Daopei Hospital musi wa 14 Kukadzi 2022. BM MRD yavo yakaratidza 0.25 per cent abnormal plasma cells. IEF yakaratidza IgG uye M protein yaive 3 g/l. PET-CT Scan yakaratidza kuwedzera kutora mu testis kunyanya iyo chaiyo iyo yakawedzerwawo pakuongororwa. Testicular biopsy yakaitwa iyo yakaratidza masero eplasma akaipa. Murwere akasarudzwa kuti aite CART cell therapy. Preconditioning yakaitwa nefludarabine uye cyclophosphamide kwemazuva matatu. CAR-T Masero akaiswa pazuva 0 (4/3/2222). Chiyero chakapihwa chaive 0.5X10^6/kg. Mushure mekuisirwa, murwere aive neutropenia fever iyo yaidzorwa neiv maantibiotic. Right testicular kuzvimba zvishoma nezvishoma kwakaderedzwa kusvika kune yakajairika saizi. Pazuva 28 BM kuongororwa kwakanga kusina kunaka kune masero eplasma. Murwere akadzingwa kubva kuLu Daopei nekutevera nguva dzose munzvimbo yehematology muguta rake.