Acute Lymphoblastic Leukemia(T-ALL)-10
Mumwe mukomana ane makore gumi nematatu okuberekwa anonzi Yangyang anobva kuPanzhihua, Sichuan Province, akaita chirwere cheCAR-T chichiteverwa nekusimwa pabhiriji.
Yangyang akatanga ne "mavanga akapararira mumuviri wese achiperekedzwa nekuneta" musi waKubvumbi 12, 2021. Akaonekwa aine acute lymphoblastic leukemia (T-cell subtype) ine intracranial hemorrhage uye hutachiona hwemapapu hwakasimbiswa nemwongo bvunzo yeMICM pachipatara chikuru mu. Chongqing. Akaita 3 cycles yechemotherapy pane chimwe chipatara, asi bone marrow haana kupindura. Pakazosvika June, akatanga kushaya simba mumakumbo maviri ezasi uye aisagona kufamba.
Musi waChikunguru 1, 2021, Yangyang akapinzwa mudhipatimendi redu reHematology Ward 2. Akanyoresa muCD7 CAR-T yekiriniki yekuedza musi waChikunguru 8 uye akagamuchira autologous CD7 CAR-T cell infusion musi waChikunguru 26 yeimmunotherapy. Mazuva gumi nematanhatu mushure mekuiswa, bone marrow morphology yakaratidza kuregererwa, uye kuyerera kwe cytometry yakaratidza 0.07% inofungira yakaipa immature T lymphoblasts. Mushure mekurapwa kwemuviri, akawanazve kugona kufamba akazvimiririra. Pakazosvika zuva 31 mushure mekuisirwa, mwongo wake wakawana kuregererwa kwakakwana.
Parizvino, Yangyang akatamisirwa kuWard 6 yeBone Marrow Transplantation department kuti awedzere kurapwa. Dr. Hai weWard 6 akataura kuti Yangyang anga achishandira pamwe uye ane tariro munguva yese yekurapa kwake. Akaitwa allogeneic hematopoietic stem cell transplantation (kubva kuna baba vake) musi waGunyana 28. Mamiriro ezvinhu akagadzirwa nevaaishanda navo veDhipatimendi reHematology pakusimwa kwake nebhiriji akaongwa zvikuru.
Varwere ava, vasati vanyoreswa muCD7 CAR-T kliniki yekuedza, yakaratidza zviratidzo zvakasiyana-siyana zvakadai sekudzokazve kwemashure, T/myeloid dual expression, refractory/resistant acute T-cell leukemia, central nervous system leukemia, intracranial hemorrhage, uye chirwere chemapapu. Mushure mekuongororwa uye kurapwa neCD7 CAR-T kurapwa, vese vakawana kuregererwa kwakakwana, kusangana nezvinotarisirwa.
Ludaopei Hospital yakanyatsoongorora mumunda weCAR-T kurapwa uye yakaunganidza ruzivo rwakapfuma mukutonga CRS. Kuvazhinji vatori vechikamu, mhedzisiro yakaipisisa yaive fivha yakanyanya. "Ndinogona kuwana kuregererwa kwakakwana, saka fivha haisi chinhu! Ndinoda kuti vanhu vakawanda vazive kuti Ludaopei anogona kuita CAR-T!" akadaro Yangyang kubva kuFujian pakubuda.
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