Acute Lymphoblastic Leukemia(T-ALL)-09

Mumwe mudzidzi wepayunivhesiti anonzi Mengmeng anobva kuYanjiao, Guizhou, akawana kurapwa kunoshanda paLudaopei Hospital.

Mengmeng, mukadzi, ane makore makumi maviri nerimwe ekuberekwa, akaunzwa kukiriniki yedu yevarwere kunze kwaChikumi 22, 2021, nekuneta kunoramba kuripo. Kuongororwa kweropa kwakaratidza WBC 479 × 10 ^ 9/L. Kumwe kuongorora mwongo kwakasimbisa acute lymphoblastic leukemia (T-cell subtype). Akaita makomisheni maviri echemotherapy, asi leukemia yakaramba isingaite, aine MRD (diki residual chirwere) pa56.01%, uye aivewo nechepakati tsinga yekubatanidzwa kweleukemia.

Musi waNyamavhuvhu 13, autologous lymphocytes yakaunganidzwa uye chemotherapy yakaitwa. Musi wa30 Nyamavhuvhu, Mengmeng akagamuchira CD7 CAR-T cell infusion. Vhiki mbiri mushure mekuisirwa, kuongororwa kwemwongo wemapfupa kwakaratidza kuregererwa kwakakwana, kusaziva kweMRD, uye kutonga kwepakati tsinga system leukemia. Akasangana negiredhi 1 cytokine kuburitsa syndrome (CRS) maitiro asina yepakati tsinga system yakashata maitiro.