Acute Lymphoblastic Leukemia(T-ALL)-07
Musikana weMiao anowana kuregererwa kuzere mushure mekurapa kweCAR-T zvichitevera kudzoka shure kwekutapurirana.
Amei, mudzidzi wepashure kubva kuHunan werudzi rweMiao, akange aburitsa mapepa maviri eSCI. Musi waApril 2, 2020, akapinzwa muchipatara chepurovhinzi nekuda kwefivha. Kuongororwa kwemwongo webhonzo kwakaratidza kuti ane acute lymphoblastic leukemia (T-ALL). Mushure mekosi dzakawanda dzekemotherapy pachipatara chekunze, mwongo wake wakaramba uri mukuregererwa. Musi waNovember 2, 2020, akaita allogeneic hematopoietic stem cell transplant kuchipatara chedu (mukoma-kune-sisi, HLA 7/10 mechi). Mushure mekutapurirana, maseru akaiswa zvinobudirira, uye ongororo dzemwongo dzekutevera dzakaratidza kuregererwa kwakasimba.
Musi waChikumi 16, 2021 (mwedzi minomwe mushure mekutapurirana), kuongororwa kwemaitiro kwakaratidza kudzoka kuzere kweleukemia yake. Kurapwa kwekenza kwakatevera kwakakundikana kudzora hosha yacho, uye akatanga utachiona hwemabayo neherpes virus, nemaronda omumukanwa anorwadza achiita kuti kumedza kuve kwakaoma. Akapinzwa muwadhi yechipiri yedhipatimendi rehematology uye akanyoresa muCD7 CAR-T yekiriniki yekuedza.
Chikwata chekurapa chaDirector Yang Junfang chakapa kurapa kwekurwisa hutachiona, kunyaradza marwadzo, uye kuisirwa ropa rakawanda uye maplatelet. Nekuda kwekuremerwa kwebundu (80% kuputika mumwongo uye 97% kuputika muropa reparutivi), hazvina kukwanisa kuunganidza masero ake. Peripheral blood lymphocytes kubva kumupi (mukoma wake) akaunganidzwa akatumirwa kukambani yebiotech yeCAR-T cell tsika.
Musi waNyamavhuvhu 10, 2021, masero eCD7 CAR-T anotorwa nevapi akadzorerwa. Mushure mekudzoreredzwa, masero eCAR-T akawedzera kusvika 54.64% muropa reperipheral, aine fever chete uye pasina yakakosha cytokine release syndrome (CRS) kana graft-versus-host disease (GVHD). Bone marrow kuongororwa pazuva 16 mushure mekudzorerazve kwakaratidza kuregererwa kwakakwana, ne 54.13% masero eCAR-T mumapfupa emapfupa. Pazuva 36, mwongo wakaramba uchiratidza kuregererwa kwakasimba. Parizvino, chimiro chake chendangariro, kurara, uye kuda kudya zvakanaka, uye ari kunaya zvakanaka.
tsananguro2