Acute Lymphoblastic Leukemia(T-ALL)-06
Murwere wevana ane makore maviri ekuberekwa ane T-ALL anowana kuregererwa mushure mekurapwa kweCAR-T zvichitevera kutenderera kunopfuura gumi kwekemotherapy yakasimba.
Xiaohong ane makore maviri okukura wekuZhejiang akaonekwa aine leukemia zhizha rapfuura. Mushure meanopfuura gore rekurapwa, kuyerera kwecytometry yakaona kudzokazve, zvichiita kuti mhuri itsvage CAR-T immunotherapy paLu Daopei Hospital.
Musi waNyamavhuvhu 9, 2020, Xiaohong akapinzwa muchipatara chevana veko nekuda kwe "fivha yemazuva matatu." Bone marrow MICM kuongororwa kwakawanikwa acute lymphoblastic leukemia (T-ALL). Mushure meimwe nzira yechemotherapy, bone marrow morphology yakaratidza kuregererwa kwakakwana, uye kuyerera kwe cytometry hakuna kuona masero akaipa asina kukura. Yakazotevera yakanyanya chemotherapy pamusoro pemakosi e11 yakachengetedza kuregererwa kwakakwana kwemwongo.
Musi waGunyana 3, 2021, iyo yekutevera bhonzo puncture yakaratidza kuregererwa kwakakwana mumorphology, asi kuyerera kwe cytometry kwakaratidza 1.85% yakaipa masero asina kukura. Achitsvaga kumwe kurapwa, Xiaohong akaendeswa kuYanda Lu Daopei Hospital musi waSeptember 24. Pakubvumirwa, bone marrow morphology yakanga ichiri mukuregererwa kwakakwana, asi immunophenotyping yakaratidza 0.10% yakaipa immature T lymphocytes.
Tichifunga nezvezera rechidiki raXiaohong nekuenderera mberi kwechirwere ichi kunyangwe akadarika gumi ekurapa kwakanyanya, boka rekurapa muwadhi yechipiri yedhipatimendi rehematology rakasarudza kuti Xiaohong aigona kunyoresa muCD7 CAR-T yekiriniki.
Musi waGunyana 30, 2021, masero eropa ekutenderera akaunganidzwa eCAR-T cell tsika. Musi waGumiguru 10, Xiaohong akagamuchira FC regimen chemotherapy. Musi waOctober 13, kuputika kwepfupa kwakaratidzira zvishoma kudarika 5% kuputika mu morphology, uye kuyerera kwe cytometry yakaratidza 0.37% yakaipa immature T masero. Musi wa15 Gumiguru, masero eCD7 CAR-T akadzorerwa.
Musi waNdira 3 (mazuva makumi maviri mushure mekudzorerazve), kuputika kwemwongo wepfupa kwakaratidza kuregererwa kwakakwana mu morphology, pasina masero asina kunaka anoonekwa nekuyerera kwe cytometry. Mamiriro aXiaohong abva adzikama, uye akaendeswa kudhipatimendi rekudyara kuti agadzirire allogeneic hematopoietic stem cell transplant.
Xiaohong akanga asingasviki gore paakatanga kurwara uye akatsungirira kwerinopfuura gore rekurapwa nezvinodhaka. Kubudirira kubatanidza kuisirwa mushure mekurapwa kweCD7 CAR-T kwakapa chombo chine simba kukunda zvachose chirwere ichi.
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