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FUCASO: Le Revolutionary Fully-Human BCMA CAR-T Therapy ma le le mafaatusalia le aoga ma le saogalemu

FUCASO: Le Revolutionary Fully-Human BCMA CAR-T Therapy ma le le mafaatusalia le aoga ma le saogalemu
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FUCASO: Le Revolutionary Fully-Human BCMA CAR-T Therapy ma le le mafaatusalia le aoga ma le saogalemu

FUCASO ose fa'afouga BCMA-fa'atatau CAR-T togafitiga e IASO BIO, ofoina le mafaatusalia aoga ma le saogalemu mo toe fa'afo'i po'o refractory tele myeloma. Faʻatasi ai ma le maualuga o tali, faʻamagaloina umi, ma se talaaga saogalemu malosi, FUCASO e maua ai le faʻamoemoe fou mo tagata mamaʻi ma faʻatulagaina se tulaga fou ile togafitiga CAR-T.

    Faafesootai matou
    fa'amatalaga o oloa
    Tulaga Autu ole FUCASO
    Manuia Falemai

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    FUCASO, atiaʻe e Nanjing IASO Biotechnology, ose suatiaina eleele CAR-T togafitiga faʻapitoa e faʻatatau i le B-cell maturation antigen (BCMA). O lenei togafitiga e tu i fafo mo lona aoga e le mafaatusalia le aoga ma le saogalemu o talaaga, e maua ai se faʻamoemoe fou mo tagata mamaʻi ua toe faʻafoʻi pe refractory tele myeloma (r / rMM). Faʻamaonia e le National Medical Products Administration (NMPA) ia Iuni 30, 2023, FUCASO ua uma ona faʻaalia le manuia tele i le falemaʻi.

    Tulaga Maualuga Tali: FUCASO o loʻo faʻamaualuga le aofaʻi o le tali atoa (ORR) o le 98.9% ma le tali atoa (CR) fua faatatau o le 82.4%, e matua maualuga atu nai lo isi togafitiga avanoa.

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    Faamagalo tumau: O maʻi na togafitia i le FUCASO ua faʻaalia le 12-masina Alualu i Luma-Free Survival (PFS) fua faatatau o le 85.5%, e faʻaalia ai le faʻamagaloina umi ma le faʻaleleia atili o le olaga.

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    Fa'amatalaga Saogalemu: Fa'atasi ai ma le ≥3 grade Cytokine Release Syndrome (CRS) o lo'o tupu i na'o le 1% o ma'i ma e leai ni fa'amatalaga na lipotia mai o le ≥3 grade Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), FUCASO e ofoina atu se togafitiga sili atu le saogalemu pe a fa'atusatusa i isi togafitiga CAR-T. .

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    Tau-Tauleleia: FUCASO tau togafitiga e matua itiiti ifo nai lo togafitiga tutusa o loʻo maua i le Iunaite Setete, ma avea ai ma filifiliga talafeagai mo le lautele lautele o gasegase.

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    A'ota'iga i le Lalolagi: Ua faʻatuina e le IASO BIO se fesoʻotaʻiga faʻapitoa mo togafitiga i Saina, e mafai ona tautua tagata mamaʻi mai le salafa o le lalolagi faʻatasi ai ma auaunaga tuʻufaʻatasia mai faʻatalanoaga i le maeʻa o togafitiga.

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    O le gasegase muamua na togafitia i le FUCASO ua ausia le lima tausaga o le ola e aunoa ma le kanesa, o se mataʻina mataʻina pe a faʻatusatusa i le median Progression-Free Survival (PFS) na o le 2.9 masina ma le tausiga masani. O lo'o fa'amaninoina ai le malosi ole FUCASO e suia ai le laufanua o togafitiga mo le tele ole myeloma.

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