Ose Va'aiga Atoa o Togafitiga o le Leukemia
Fa'ailoga o le CAR-T
●B-cell acute lymphoblastic leukemia
●Mieloma tele
●Leukemia lymphocytic tumau
●lymphoma e le o Hodgkin
●Fa'asalalauina le lymphoma sela tele B
●SLE (Systemic Lupus Erythematosus)
●Myasthenia gravis
●O isi faʻamaʻi autoimmune
Lelei le fa'atinoga ole falema'i CAR-T
Fa'ailoga mo CD19+20CAR-T:O gasegase e maua ile B-cell non Hodgkin's lymphoma
Tasi le masina CR fua | E tasi le masina PR fua faatatau | Tasi le masina OR fua faatatau | CRS≥3 | CRES≥3 |
71.95% (59/82) | 25.6 (21/82) | 97.55 (80/82) | 12.19% (10/82) | 0 |
Fa'ailoga mo CD19+22CAR-T:Togafitiga o le CD19 ua toe fa'afo'i ma fa'ama'i ma'i ma'i B-lymphocytic leukemia
Tasi le masina CR fua | E tasi le masina PR fua faatatau | Tasi le masina OR fua faatatau | CRS≥3 | CRES≥3 |
92.1% (35/38) | 7.9% (3/38) | 100% (38/38) | 15.79% (6/38) | 0 |
Fa'ailoga mo le BCMACAR-T:Togafitiga o le tele o myeloma ua toe fa'afo'i ma fa'aletonu
Tasi le masina CR fua | E tasi le masina PR fua faatatau | Tasi le masina OR fua faatatau | CRS≥3 | CRES≥3 |
72.41% (21/29) | 27.59% (8/29) | 100% (29/29) | 6.9% (2/29) | 0 |
O Tatou Fa'amanuiaga
● Togafitiga Fa'apitoa: O togafitiga CAR-T taʻitasi e faʻapitoa i le tagata maʻi, faʻamautinoa le maualuga o le faʻamoemoeina ma le lelei o togafitiga.
● Eseese Filifiliga Taulai: Faʻatasi ai ma le tele o faʻasologa o antigens, e aofia ai le CD7, CD19, CD20, CD22, ma le BCMA, oa tatou oloa CAR-T e ofoina atu le faʻaogaina e le mafaatusalia i le togafitia o maʻi faʻamaʻi hematological ma faʻamaʻi autoimmune.
● Fa'amaonia Manuia Fa'afoma'i: O a matou togafitiga CAR-T ua faʻaalia le aoga tele i le tele o faʻamaʻi faʻamaʻi, faʻatasi ai ma faʻamagaloga mataʻina ma faʻamatalaga saogalemu, faʻamalosia lo matou tulaga o se taʻitaʻi i le immunotherapy.
● Maualuluga Tau-Tauleleia: Matou te ofoina atu se faʻatauvaʻa faʻatasi ai ma togafitiga sili atu ona lelei ile tau sili atu ona faigofie pe a faʻatusatusa i isi oloa CAR-T ile maketi.
● Tekinolosi Matagofie: O le fa'aaogaina o le alualu i luma lata mai i le fa'ainisinia o kenera, o a tatou togafitiga CAR-T e fa'aalia ai le lumana'i o le kanesa ma togafitiga fa'ama'i autoimmune.
● Fesoasoani Fa'afoma'i Fa'apitoa: O la matou 'au fa'apitoa o foma'i ma tagata su'esu'e e tu'uina atu le tausiga atoatoa mai fa'atalanoaga muamua e ala i le fa'afoega o togafitiga ma le tulitatao.
O sela CAR-T ua lauiloa nei mo lo latou aoga i gasegase e leʻi tali atu i togafitiga faʻaleaganuʻu e pei o le chemotherapy poʻo le totoina o gaʻo ponaivi. Ua fa'ailoa e le fa'alapotopotoga fa'afoma'i a le lalolagi le malosi o le suatiaina o le eleele o le CAR-T togafitiga i le suia o taunu'uga o gasegase.
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