Intambara ya Wu: Kubabazwa na myeloma myinshi

Patient Wu, umugabo w'imyaka 71, bamusanganye indwara ya myeloma myinshi.

Yashakiye kwivuriza mu kigo mpuzamahanga cy’ubuvuzi cya Bioocus mu 2022 kandi anyuzwe cyane n’ubuvuzi bwe. Indwara ya mbere y’indwara yerekanaga ibibyimba bya MRI na T5T scan, harimo kuvunika T10, T11, na L1 hamwe no kuvunika amagufwa. Byongeye kandi, ibimenyetso bito bidasanzwe byagaragaye mu mubiri wa L2. Intanga ya vertebral biopsy yemeje plasma selile myeloma. Ubundi bushakashatsi bwakozwe bwerekanye plasma ya prokaryotic igizwe na 46% ya biopsy yo mu magufa, hamwe na selile zidasanzwe zidasanzwe zigizwe na 14% muri cytometrike. Amagufwa ahuza biopsy yerekanye 70% problastoma. Isesengura ry’amafi ryerekanye igihombo cya gene muri lq21 (CKSIB) na 1m32 (CDKN2C), mugihe ikizamini cya FTSH cyari cyiza cyo gusiba gene p53, kandi ICH yari mbi mubizamini by'Amafi. Isuzumabumenyi rya nyuma ryabaye osteoblastique follipoma (ubwoko bwurumuri rwa L), DS ikurikirana mugice cya B, ISS ikiciro cya III, na RISS ikabera mu cyiciro cya II. Patient Wu yashimiye ubuvuzi bwuzuye kandi bwihariye butangwa n'ikigo nderabuzima.

Amateka yo kuvura mbere:

Kugaragara kwa clinique ya myeloma myinshi iratandukanye, cyane cyane harimo kubura amaraso, kubabara amagufwa, kubura impyiko, kwandura, kuva amaraso, ibimenyetso byubwonko, hypercalcemia, hamwe nintebe ya amyloide. Ibitaro byakoze imiti igabanya ubukana kandi bikosora amaraso make na platine nkeya. Nyuma y'amezi 2 nyuma ya BCMA CAR-T yinjije selile, ibipimo byumurwayi byagarutse buhoro buhoro, kandi ubuzima bwe bwaragenzuwe. Ikigo cy’ubuvuzi mpuzamahanga cya Bioocus cyakomeje gukurikirana umurwayi kugira ngo ingaruka z’ubuvuzi zihamye.