Ubuvuzi bwa TIL bwashyizwe ahagaragara: Gutohoza imiterere ya Kanseri Immunotherapy

Ubuvuzi bwa TILs burimo gukuramo lymphocytes (TILs) zibyimba-zifata ibibyimba, arizo ngirabuzimafatizo zisanzwe zirwanya ibibyimba mu mubiri w’umurwayi, mu kibyimba no kuzihinga ari nyinshi muri laboratoire. Izi TIL zikora noneho zisubizwa mumubiri wumurwayi kugirango zongere imbaraga z'umubiri zo kwibasira no kwica selile. TILs ikora mukumenya ibimenyetso byihariye kuri selile ya kanseri no gutangiza ubudahangarwa bw'umubiri kubarwanya, amaherezo bikaviramo kwangirika kw'ibibyimba.

Dufatiye ku bisubizo by’ubuvuzi byacu, muri rusange imikorere ya TILs monotherapy igera kuri 40%, bikaba aribwo buryo bwiza bwo kuvura ibibyimba usibye kubagwa muri iki gihe. Ubuvuzi bumwe cyangwa bwinshi buzahuzwa hamwe nubuvuzi bwa Tils, buzamura igipimo cyiza muri rusange kugera kuri 80%. Ubuvuzi bukomatanyije bugamije kugabanya umuvuduko wibibyimba mugihe gito, kandi tils itanga amahirwe kumurwayi kugirango akire igihe kirekire.

Umwihariko:ibibyimba byihariye T selile ikangurwa na antigens yibibyimba, bizwi na TCR nyinshi

Ubukonje bukomeye:imvugo nini ya reseptor ya chemokine, tropism ikomeye yibibyimba, nibikorwa byihuse

Kwica ibibyimba:TILs irakorwa kandi ikongerwa kugeza 109-1011, kandi kanseri ya kanseri isigaye nyuma yo kubagwa

Ingaruka zikomeza:Umubare wibuke T selile ni ndende, kandi zirashobora kubaho mumubiri igihe kirekire kandi zigakomeza gukurikiranwa

Umutekano muke:gukuramo, amplification, nta reaction yo kwangwa, na SAE ya selile TILs kubarwayi ubwabo

Ubuvuzi bwa Tils bwagaragaye neza muriNSCLC (kanseri y'ibihaha itari ntoya),Melanoma, Kanseri y'ibere,Kanseri y'inkondo y'umura,na Kanseri ya Ovarian. 

Usibye gukuramo kubaga ibibyimba byibanze, ibibyimba bitagaragara byumubiri, lymph node, pleural effusion, ascite, nibindi, birashobora no kugerageza kubikuramo. Urutonde rwimikorere nuburyo bukurikira: ibisebe byibanze ≥ metastatic lesion ≥ lymph node ≥ ascites.

Gahunda yacu yo guhinga TILs yigenga igera ku ntsinzi ya 85%. Hamwe nimiterere isanzwe ya c1cm3, miliyari za TIL zirashobora guhingwa, kandi selile zigaragaza ibikorwa bya cytotoxique. "

1.TIL ni selile yumurwayi wenyine, ntakibazo rero cyo kwangwa, kurinda umutekano muke.

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3.Ibindi bitekerezo bibi byavuzwe mubushakashatsi harimo trombocytopenia, febrile neutropenia, hypertension, nibindi, ahanini biterwa na TIL ifatanije nindi miti nka chimiotherapie mbere yo kuvurwa (cyclophosphamide + fluorouracil), IL-2, PD-1 antibodies za monoclonal, nibindi