Lupus Sisitemu Erythematosus (SLE) -04

Ku myaka 7, Yaoyao (izina ry'irihimbano) yatangiye kubona ko mu maso he havutse ibisebe bitukura, bigenda bikwira mu mubiri we. Kuruhande rw'ibi bimenyetso, yahuye n'ibisebe byo mu kanwa ndetse akanababara ingingo, bituma umuryango we wivuza. Nyuma yo kwisuzumisha neza mu bitaro, Yaoyao bamusanganye indwara ya lupus erythematosus (SLE), indwara ya autoimmune izwiho amasomo akomeye kandi atateganijwe.

Mu myaka itatu, Yaoyao yagiye kuvurwa cyane no gukurikiranwa buri gihe mu bitaro. Nubwo imiti yiyongera cyane hafi yimiti, ubuzima bwe bwerekanye ko butameze neza. Na none kandi, proteinuria ye, yerekana uruhare rwimpyiko muri SLE, yakomeje kwiyongera, bitera umubabaro n’impungenge mu bagize umuryango we.

Binyuze mu nshuti yizewe yoherejwe, Yaoyao yagejejwe mu bitaro bya Lu Daopei, aho yitabiriye igeragezwa ry’amavuriro CAR-T. Nyuma y’isuzuma rikomeye, yakiriwe mu rubanza ku ya 8 Mata. Nyuma yaho, ku ya 22 Mata, yakusanyirijwe mu kagari, maze ku ya 12 Gicurasi, ahabwa ingirabuzimafatizo za CAR-T. Gusohoka neza ku ya 27 Gicurasi byaranze igihe gikomeye mu rugendo rwe rwo kwivuza.

Mu kwezi kwe kwa mbere yakurikiranye, inzobere mu buvuzi zabonye iterambere rigaragara, cyane cyane igabanuka rya proteinuria. Mu gusurwa kwakurikiyeho, uruhu rwe rwari rwarazimye, hasigaye gusa umusaya ku itama ry'iburyo. Icy'ingenzi, proteinuria ye yari yarakemuye burundu, kandi amanota ye yerekana ibikorwa bya SLE Disease Activity (SLEDAI-2K) yerekanaga indwara yoroheje, itageze kuri 2.

Yaoyao yatewe imbaraga nubuvuzi bwa CAR-T, Yaoyao yagiye buhoro buhoro imiti ye ikurikiranwa neza. Igitangaje ni uko amaze amezi arenga ane adafite imiti, ahamya ko imiti ihoraho yagezweho binyuze muri ubu buryo bwo kuvura udushya.

Urugendo rwa Yaoyao rushimangira imbaraga zo guhindura imiti ya CAR-T mugucunga imiterere ikabije ya autoimmune nka SLE, itanga ibyiringiro nibisubizo bifatika aho imiti gakondo ishobora kugabanuka. Ubunararibonye bwe ni urumuri rwicyizere kubarwayi nimiryango bahura nibibazo bisa, byerekana ejo hazaza heza h'ubuvuzi bwihariye mugucunga indwara ziterwa na autoimmune.