Lupus Sisitemu Erythematosus (SLE) -03

Muri Kanama 2016, Madamu A w'imyaka 20 y'amavuko yagize ibibara bitukura bitukura ku mubiri we ndetse no kugira umuriro kenshi, kandi yari afite platine nkeya, amezi arindwi nyuma yo kubyara. Nyuma y’ibizamini byinshi mu bitaro byaho, bamusanganye indwara ya lupus erythematosus (SLE) mu bitaro byo mu ntara. Mu Kwakira muri uwo mwaka, yatangiye kwivuriza mu bitaro byaho.

Madamu A yagize ati: "Mu myaka irindwi ishize, byabaye ngombwa ko nsura ibitaro buri kwezi kugira ngo mbandikire, nsuzume kenshi amaraso, nipimisha inkari, kandi imiti ihoraho ndetse no gutera inshinge, ariko indwara yakomeje kugaruka, birababaza cyane". Mu rwego rwo kuvura indwara ye, umugabo we yamujyanye mu bitaro byinshi, ariko amafaranga menshi ntiyigeze yorohereza ubuzima bwe. Amaherezo, yaje kurwara lupus nephritis na encephalopathie, maze muri Nzeri 2022, abagwa mu bwonko. Madamu A yumvise ko CAR-T ivura ishobora kuvura SLE, Madamu A yasabye ubufasha mu bitaro byacu, aho itsinda ry’impuguke ryahise risesengura imiterere ye.

Muganga yabisobanuye agira ati: "Igihe uyu murwayi yemerwaga bwa mbere, yari yararwaye indwara yo mu nda, proteinuriya ikomeye, ndetse na antibodiyite nziza. Yari yarahawe imisemburo gakondo ndetse n’ubuvuzi bwa immunosuppressive, ndetse n’ubuvuzi burindwi bwo kuvura ibinyabuzima, ariko nta na kimwe cyagize akamaro. Yagize lupus. encephalopathie, hypertension yimpaha, fibrosis yo mu bihaha, hamwe na biopsy ye yimpyiko byerekanaga lupus ikora. Ibi byerekanaga ko kuvura gakondo n’ibinyabuzima ntacyo byatwaye. " Ugereranije n’imiti gakondo cyangwa antibodiyite za monoclonal, selile CAR-T irashobora kwinjira mu mbogamizi zinyama, ikwirakwiza cyane mu ngingo, kandi ikagira ingaruka za cytotoxique, cyane cyane irwanya selile B cyangwa selile ya plasma mu cyuho cya tissue itagerwaho na antibodi ya monoclonal. Hatabayeho 'imbuto z'indwara,' autoantibodies z'umurwayi zigabanuka buhoro buhoro, ibyuzuzanya bisubira mu buryo, kandi ibimenyetso bigenda byoroha cyangwa bikazimira. "Kubera iyo mpamvu, umurwayi yavuwe neza CAR-T.

Madamu A yagize ati: "Noneho ibibara bitukura ku mubiri wanjye byarashize, kandi sinkibakeneye imiti ya hormone cyangwa immunosuppressants. Nigeze kwisuzumisha kenshi mu maraso no mu nkari, ariko ubu ndabikenera buri mezi atandatu. Ubuzima bwanjye muri rusange ni bikomeye, kandi ibipimo byose ni ibisanzwe. Uyu munsi ni inshuro ya gatatu nkurikirana, kandi ibisubizo bivuye mu ngendo ebyiri zabanjirije iyi byari byiza, ndashimira cyane abakozi b'ubuvuzi bampaye amahirwe ya kabiri mu buzima. "