Sisitemu Lupus Erythematosus (SLE) -01

Xiaohuan w'imyaka 24 y'amavuko amaze imyaka itatu yiga ubuvuzi muri kaminuza kandi amaze imyaka igera ku 10 arwaye sisitemu ya lupus erythematosus (SLE). Xiaohuan amwenyura cyane ati: "Nansuzumye mfite imyaka 10, kandi umuganga yavuze ko bigoye gukira, ko nshobora kubirwanya nkoresheje imiti." Mu myaka icumi ishize, yagombaga kujya kwisuzumisha buri kwezi no kwandikirwa imiti, kandi yagiye akorerwa imiti ya hormone, imiti ikingira indwara, ndetse n’ubuvuzi bw’ibinyabuzima, ariko nta na kimwe cyagize akamaro. Yihanganiye gutakaza umusatsi cyane, guhubuka inshuro nyinshi, guhorana umuriro mwinshi, no kubabara cyane.

Nyuma y’ibizamini bitandukanye byibanze, Xiaohuan yujuje ibisabwa byose kugirango ivure CAR-T ivura SLE. Itsinda ryinzobere ryateguye neza gahunda yo kuvura ishingiye kumiterere ye kandi itegura neza gahunda yo gukusanya selile. Ku ya 28 Werurwe, gukusanya ingirabuzimafatizo ya monon nuclear byatangiye. Ku ya 22 Mata, yatangiye lymphodepleting chimiotherapie. Ku ya 28 Mata, selile zongeye gushyirwamo. Miliyoni 20 za CAR zahinduwe na T zinjiye buhoro buhoro mu mitsi ya Xiaohuan, byibasira selile lupus B, zitangiza "igitero simusiga, kibavunagura umwe umwe".

Ku ya 4 Kamena, umunsi wa 38 nyuma yo gushiramo, Xiaohuan yasubiye mu bitaro kugira ngo amukurikirane. Ibisubizo by'ibizamini byagaragaje ko ibipimo byose by'ingenzi byagabanutse kugera ku ntera isanzwe. Xiaohuan yishimye ati: "Sinkeneye imiti ya hormone; numva ubuzima butangiye."