Shawn [Izina ryanyuma ntabwo ryatanzwe] ---- Acute B-lymphocytike Leukemia (B-BYOSE)

Igeragezwa ryiza rya CAR-T rikiza Hong Kong B-BYOSE umurwayi.

Shawn, ni umusore w'imyaka 29 ukomoka muri Hong Kong. Muri Werurwe 2017, ifite ibimenyetso byumuriro, umunaniro nubusa. Yafashwe n'indwara ikaze ya B-lymphocytike leukemia mu bitaro bya Prince of Wales maze ahabwa imiti ya induction. Muri Mata yagiye gukira byimazeyo hamwe na chimiotherapie na radiotherapi. Kandi nta bidasanzwe byagaragaye muri raporo ya CSF.

Ariko, kugeza ku ya 19 Mata 2018, morfologiya ye yo mu magufa yerekanaga 10% ya gonorrhea y'ibanze na bato. Abaganga ba Hong Kong batekereza ko chimiotherapie igoye kumutera gukira burundu, gusa CAR-T ifite amahirwe menshi yo kubikora. Nyuma y’ibyifuzo by’abaganga no kugereranya igipimo n’intsinzi, Shawn yaje mu bitaro bya Lu Daopei mu Bushinwa kugira ngo yitabire ibizamini by’amavuriro CAR-T ku ya 23 Mata 2018.

Kwipimisha amagufa ya marrow biopsy yerekanaga ko atigeze akira neza kandi CD19 、 CD20 ni nziza. Nyuma yo kugirwa inama zitandukanye, abahanga mu kuvura indwara z’ubuvuzi bavuga ko yitabira igeragezwa rya CD19 + CD20 CAR-T mbere yo guterwa amagufwa. Mubibazo byacu 300 CAR-T, igipimo cyo kohereza cyuzuye ni 90%.

Ku ya 25 Mata, T-selile ya Shawn yakusanyirijwe muri laboratoire ya GMP CAR-T yo gukora ingengabihe. Nyuma yo guhindurwa genetiki, T-selile yahinduwe "chimeric antigen reseptor (CAR) T-selile". CAR ni poroteyine zifasha T-selile kumenya antigen mu ngirabuzimafatizo yibibyimba. Ingirabuzimafatizo za CAR T zimaze gukura kugeza ku buryo buhagije bwo kuvura, selile CAR T zinjizwemo kugira ngo zikureho ingirabuzimafatizo.

Shawn yakiriye amasomo 1 ya chimiotherapie ku ya 6 Gicurasi, ni iminsi 5 mbere yuko CAR-T yinjira. Gicurasi. Ku ya 11 Gicurasi, kwinjiza selile CD19 CAR-T byatanzwe nka immunotherapie selile. Nyuma yibyumweru 4 byitaweho no gucunga neza ingaruka, nta bidasanzwe byagaragaye muri raporo ifitanye isano na CSF, imigendekere ya cytometrie, amagufa ya marrow selile, ikizamini cya ADN na raporo ya CAR-T yerekanye ko yakiriye neza.

Kuba muburyo bwuzuye nuburyo bwiza kuri we bwo gusubira muri Hong Kong intambwe ikurikira - guterwa amaraso n'amagufwa.