Ubuvuzi bwa NS7CAR-T bwerekana isezerano ryo kuvura R / R T-BYOSE / LBL

Igitabo giherutse gusohoka mu kinyamakuru Blood cyibanze cyane ku bushobozi bwo kuvura selile NS7CAR-T yo kuvura indwara ya T-selile ikaze cyangwa yangiritse T-selile acute lymphoblastique leukemia (R / R T-ALL) na lymphoma T-selile (R / R T) -LBL). Ubushakashatsi bwakozwe nkikizamini cya 1 cyamavuriro (ClinicalTrials.gov: NCT04572308), cyasuzumye umutekano n’akamaro k’ubu buvuzi bushya.

Mu igeragezwa harimo abarwayi bafite R / R T-ALL / LBL bakiriye selile NS7CAR-T. Ibisubizo byagaragaje ko kuvura NS7CAR-T atari umutekano gusa ahubwo byanagaragaje ibikorwa bitangaje byo kurwanya ibibyimba. Abarwayi bavuwe na selile NS7CAR-T bagaragaje ibisubizo bikomeye byubuvuzi, byerekana ko ubwo buvuzi bushobora kuba igikoresho gikomeye cyo kurwanya kanseri itoroshye.

Abashakashatsi bari inyuma y’ubushakashatsi barimo itsinda ry’impuguke zo mu bitaro bya Hebei Yanda Lu Daopei na Hebei Senlang Biotechnology Co., Ltd. Ubushakashatsi bwabo bwerekana ko ingirabuzimafatizo za NS7CAR-T zishobora kubyara neza nta zindi genoside zahinduwe kugira ngo birinde CD7, bikoroshya inzira y’umusaruro. no kuzamura ubuvuzi bufatika.

Iyi ntambwe muri NS7CAR-T ivura selile ihuza imbaraga zihoraho zo guteza imbere uburyo bunoze bwo kuvura T-ALL na T-LBL. Isosiyete yacu nayo iratera imbere muriki gice hamwe nigicuruzwa cyacu CAR-T, twizera ko kizuzuza ibisubizo bitanga umusaruro hamwe nubuvuzi bwa NS7CAR-T.

Ibisubizo bishimishije muri ubu bushakashatsi bitanga inzira y’ubushakashatsi n’ibigereranyo by’amavuriro kugira ngo bishimangire uruhare rw’utugingo ngengabuzima twa NS7CAR-T mu kuvura indwara mbi za T-selile zisubirwamo cyangwa zangiritse. Mugihe amakuru menshi aboneka, twizere ko ubu buvuzi buzahinduka inzira isanzwe kubarwayi barwanya izo ndwara zikaze.