Ibitaro bya Lu Daopei Bidafite CD-CD19 CAR-T Ubuvuzi Bwerekana Ibisubizo Byiringiro Mubarwayi B-BOSE
Mu bushakashatsi bwibanze bwakorewe mu bitaro bya Lu Daopei, abashakashatsi batangaje ko hari intambwe imaze guterwa mu kuvura imiti igabanya ubukana cyangwa isubirwamo B ikabije ya lymphoblastique leukemia (B-ALL) ikoresheje imiti mito ya CD19 iyobowe na CAR-T. Ubushakashatsi bwitabiriwe n’abarwayi 51, bwagaragaje ko ubu buryo bushya butageze gusa ku gipimo cyo hejuru cyo kuvura (CR) gusa ahubwo cyanagaragaje umutekano mwiza.
Itsinda ry’ubushakashatsi riyobowe na Dr. C. Tong wo mu ishami rya Hematology na Dr. AH Chang wo mu kigo cy’ubushakashatsi bw’ubuvuzi cya Clinical Translational Centre mu Ishuri Rikuru ry’Ubuvuzi rya Tongji, bakoze ubushakashatsi ku ngaruka zo gutanga urugero ruto rw’utugingo ngengabuzima twa CAR-T - hafi 1 × 10 ^ 5 / kg - ugereranije na dosiye isanzwe. Ubu buryo bwari bugamije kuringaniza imiti ivura no kugabanya ingaruka zikomeye, cyane cyane syndrome ya cytokine (CRS).
Ibyavuye mu bushakashatsi byari bikomeye. Mu barwayi 42 banze / basubiwemo B-BOSE, 36 bageze kuri CR cyangwa CR hamwe no gukira kutuzuye (CRi), mu gihe abarwayi icyenda bose bafite uburwayi buke busigaye (MRD) bageze kuri negativite ya MRD. Byongeye kandi, abarwayi benshi bahuye na CRS yoroheje cyangwa yoroheje, hamwe nibibazo bikomeye byakemuwe neza hakoreshejwe ingamba zo gutabara hakiri kare.
Dr. Tong yagaragaje akamaro k’ubu bushakashatsi, agira ati: "Ibisubizo byerekana ko imiti mito ya CD19 CAR-T ivura ingirabuzimafatizo, hanyuma ikurikirwa no kwimura ingirabuzimafatizo ya allogeneic hematopoietic stem selile (allo-HCT), itanga uburyo bwiza bwo kuvura abarwayi bafite ubundi buryo buke, Ubu buryo bwo kuvura ntabwo butanga gusa ibisubizo bihanitse ahubwo binagabanya cyane ingaruka z’ingaruka mbi. "
Intsinzi yubu bushakashatsi irashimangira ubushobozi bwo kuvura ingirabuzimafatizo ya CAR-T mu kuvura indwara mbi ziterwa na hematologiya. Ibitaro bya Lu Daopei, bizwi cyane kubera ibikorwa by’ubupayiniya mu gukingira indwara ya selile, bikomeje kuyobora mu gutanga imiti igezweho ku barwayi bafite ibibazo by’indwara z’amaraso.
Mugihe ubushakashatsi bugenda butera imbere, itsinda ryubushakashatsi rifite icyizere cyo kurushaho kunoza dosiye na protocole kugirango umusaruro w’abarwayi uzamuke. Ibyavuye muri ubu bushakashatsi byasohotse mu kinyamakuruLeukemiakandi utange icyerekezo cyiza kubarwayi B-BOSE kwisi yose.