Ingaruka z'igihe kirekire za CD19 CAR T-selile yo kuvura mugusubiramo / Gusubirana Lymphoblastique Leukemia

Mu iterambere rigaragara mu bijyanye na hematologiya, ubushakashatsi buherutse gukorwa bwerekanye ingaruka z'igihe kirekire za CD19 chimeric antigen reseptor (CAR) T-selile ivura abarwayi barwaye indwara ya lymphoblastique ikaze / yisubiraho (BYOSE) nyuma ya allogeneic hematopoietic stem guhinduranya ingirabuzimafatizo (allo-HSCT). Ubushakashatsi bukurikirana abarwayi mu gihe kinini, butanga isesengura ryimbitse ku byavuyemo, butanga ubumenyi bwimbitse ku gihe kirekire n’umutekano w’ubwo buvuzi bushya.

Ubushakashatsi bwakurikiranye neza abarwayi bari baravuwe CD19 CAR T-selile nyuma yo guhura na BOSE bakurikira allo-HSCT. Ibisubizo biratanga ikizere, byerekana ko umubare munini w'abarwayi bagezeho neza, hamwe n'ibisubizo bihamye byagaragaye mu myaka yashize. Ubu bushakashatsi ntibushimangira gusa ubushobozi bwo kuvura CAR T-selile ariko kandi bugaragaza intambwe ikomeye mu kuvura indwara ziterwa na hematologiya, cyane cyane kubafite uburyo buke bwo kuvura.

Ikigeretse kuri ibyo, ubushakashatsi bwibanze ku mutekano w’ubuvuzi, utanga ingaruka zishobora gucungwa, ibyo bikaba byari bihuye n’ubushakashatsi bwabanje. Ibi bishimangira icyizere cyiyongera muri CAR T-selile yubuvuzi nkubuvuzi bufatika kandi bunoze bwo gusubiramo / kwisubiraho BYOSE, cyane cyane nyuma yo kwimurwa.

Mu gihe urwego rwo gukingira indwara rukomeje kugenda rwiyongera, ubu bushakashatsi bukaba urumuri rw’icyizere ku barwayi ndetse n’abatanga ubuvuzi kimwe, byizeza ejo hazaza aho abarwayi benshi bashobora kugera ku gihe kirekire. Ibyavuye mu bushakashatsi ntabwo bigira uruhare gusa mu bimenyetso bigenda byiyongera bishyigikira imiti ya CAR T-selile ahubwo binatanga inzira y’ubushakashatsi bwimbitse bwo kunoza no kwagura imikoreshereze y’amavuriro.

Hamwe n'iryo terambere, umuryango w'abaganga wegereye guhindura uburyo bwo kuvura indwara ziterwa na malatologiya, bitanga ibyiringiro bishya kubarwayi bahanganye nibi bibazo bitoroshye.