Ubuvuzi bushya bwa CAR-T Ubuvuzi buhindura uburyo bwo kuvura indwara mbi ya B selile
Mu isuzuma riherutse gusohoka mu kinyamakuru cy’ikigo cy’igihugu gishinzwe kanseri, impuguke z’ibitaro bya Lu Daopei, ziyobowe na Dr. Peihua Lu, hamwe n’abafatanyabikorwa bo muri kaminuza ya Texas MD Anderson kanseri ya kanseri, bagaragaje iterambere rigezweho muri CAR-T kuvura selile yo kuvura indwara ya B-selile. Iri suzuma ryuzuye rivuga ku buryo butandukanye bwo guhanga udushya, harimo n’ihindagurika ry’imiterere y’akagari ka CAR-T hamwe no guhuza imiti ivura ingirabuzimafatizo, kugira ngo imikorere n’umutekano bivurwe by’indwara nka lymphoma itari Hodgkin (NHL) na lymphoblastique ikaze (BYOSE) ).
Indwara mbi ya B-selile itera ibibazo bikomeye bitewe nubushake bwabo bwo gusubira inyuma no guteza imbere kurwanya imiti isanzwe. Itangizwa rya chimeric antigen reseptor (CAR) T yahinduye imiterere yubuvuzi, itanga ibyiringiro bishya kubarwayi bahura na kanseri yibasira. Ubushakashatsi bwerekana uburyo selile CAR T ishobora guhindurwa hamwe nibisekuru byinshi byashushanyije, bikubiyemo ibintu byateye imbere nka reseptor ya bispecificateur na domaine ya Costimulatory, kugirango bigabanye neza selile yibibyimba kandi bigabanye amahirwe yo kongera kubaho.
Ibitaro bya Lu Daopei byabaye ku isonga mu bushakashatsi bw’akagari ka CAR-T no gukoresha amavuriro, bugaragaza intsinzi idasanzwe mu gutera indwara ndende. Uruhare rw'ibitaro muri uyu murimo w'ubupayiniya rushimangira ubushake bwo guteza imbere imiti ya kanseri no gutanga ubuvuzi bugezweho. Iri suzuma ryerekana kandi ubushobozi bwo guhuza imiti ya CAR-T hamwe n’ubundi buvuzi, nka immunotherapie hamwe n’ubuvuzi bugamije, kugira ngo tuneshe uburyo bwo kurwanya no kunoza umusaruro w’abarwayi.
Iki gitabo cyerekana imbaraga zakozwe n’abashakashatsi mpuzamahanga n’abaganga mu guhashya imipaka yo kuvura kanseri. Ibyavuye mu bushakashatsi bitanga umusogongero w'ejo hazaza h’ubuvuzi bwa oncologiya, aho ubuvuzi bwihariye kandi bushya bushobora guhindura ubuzima bw'abarwayi barwanya indwara mbi ya selile B. Umusanzu wibitaro bya Lu Daopei muri uru rwego ni urumuri rwicyizere, rutera imbere kuvura kanseri neza kandi neza.