Kongera imbaraga za Antitumor ya 4-1BB ishingiye kuri CD19 CAR-T selile yo kuvura B-BYOSE

Mu bushakashatsi bukomeye bw’ubuvuzi bwakozwe n’ibitaro bya Lu Daopei n’ikigo cya Lu Daopei Institute of Hematology, abashakashatsi basanze ingirabuzimafatizo za CD19 CAR-T zishingiye kuri 4-1BB zitanga ubundi buryo butanga ikizere ku ngirabuzimafatizo gakondo ya CD28 ishingiye kuri CAR-T yo kuvura ibyasubiwemo cyangwa byanze bikunze. B selile ikaze lymphoblastique leukemia (r / r B-BYOSE). Ubu bushakashatsi, bukubiyemo iperereza rikomeye ry’ubuvuzi n’ubushakashatsi bwakozwe mbere y’ubuvuzi, bwerekanye ko selile 4-1BB CAR-T idatanga gusa imbaraga zo kurwanya antitumor gusa ahubwo inagaragaza ko abarwayi bakomeza kwihangana ugereranije na CD28.

Itsinda ry’ubushakashatsi bw’ibitaro bya Lu Daopei ryagereranije neza imikorere yubu bwoko bubiri CAR-T. Bavumbuye ko, muburyo bumwe bwo gukora, selile 4-1BB CAR-T zagize ingaruka zikomeye kuri antitumor ku kigero cyo hasi kandi zitera ibintu bibi cyane ugereranije na CD28 CAR-T. Ibyavuye mu bushakashatsi byerekana ko ubuvuzi bwa CAR-T bushingiye kuri 4-1BB bushobora gutanga uburyo bwiza bwo kuvura abarwayi barwaye r / r B-BYOSE.

Ibyavuye mu bushakashatsi bishimangira ubwitange bw’ibitaro bya Lu Daopei mu guteza imbere indwara z’amaraso no gukingira indwara, bitanga ibyiringiro ku barwayi batitabira imiti isanzwe. Ubushakashatsi bwakurikije amahame mbwirizamuco kandi bwemerwa na komite ishinzwe imyitwarire y’ibitaro bya Lu Daopei, bushimangira uruhare rw’ibitaro mu kuyobora ubushakashatsi bushya mu buvuzi bwa CAR-T.

Hamwe n'iryo terambere, ikigo cya Lu Daopei Institute of Hematology gikomeje kuba imbibi nshya mu bushakashatsi mu by'ubuvuzi, gitanga uburyo bwo kuvura no kunoza umusaruro w'abarwayi. Iri terambere ni ikimenyetso cyubwitange nubuhanga bwitsinda ryubuvuzi nubushakashatsi byibitaro bya Lu Daopei.