Inyigo Yibanze Yerekana Umutekano ningirakamaro byubuvuzi bwa CAR-T mu kuvura indwara mbi ya B-selile
Ubushakashatsi buherutse gukorwa na Dr. Zhi-tao Ying wo mu bitaro bya Kanseri bya Kaminuza ya Peking bwerekanye ibisubizo bitanga umusaruro mu kuvura indwara mbi ya B-selile yanduye kandi yangiritse ikoresheje imiti mishya ya chimeric antigen reseptor T (CAR-T) ivura selile, IM19. Byanditswe muriIkinyamakuru cyo mu Bushinwa cy’ibiyobyabwenge bishya, ubushakashatsi bwerekana imbaraga zikomeye zo kuvura IM19 kubarwayi bananiwe uburyo busanzwe bwo kuvura.
Ubushakashatsi bwakorewe ku barwayi 12, bugabanijwe kimwe hagati y’ababana na B-selile idafite lymphoma ya Hodgkin (NHL) na lymphoblastique B-selile ikaze (B-BYOSE). Abarwayi bavuwe bafite dosiye zitandukanye za selile IM19 CAR-T, zashyizwemo nyuma yuburyo bwo kwisuzumisha burimo fludarabine na cyclophosphamide. Intangiriro yibanze yubushakashatsi yarimo gusuzuma igipimo rusange cyibisubizo, CAR-T gukomera kwakagari, kurekura cytokine, no gukurikirana ibintu bibi.
Shows Igishushanyo cyerekana gukira kwa NHL na B-BOSE abarwayi）
Igitangaje ni uko abarwayi 11 kuri 12 bageze ku gukira burundu, hamwe na IM19 ikwirakwizwa mu maraso yabo. Ubuvuzi bwatumye cytokine yiyongera nka interleukin-6 na interleukin-10, byerekana ubudahangarwa bw'umubiri. Icy'ingenzi, nta n'umwe mu barwayi wigeze agira syndrome ikabije ya cytokine cyangwa se CAR-T ifitanye isano na encephalopathie selile, bishimangira uburyo bwiza bwo kuvura.
Ubushakashatsi bwakozwe nitsinda ryakoranye n’ibitaro bya kanseri ya kaminuza ya Peking, ibitaro bya Hebei Yanda Lu Daopei, n’imiti ya Beijing Immunochina. Dr. Ying, umwanditsi mukuru, azobereye mu gusuzuma no kuvura lymphoma mbi, naho Dr. Jun Zhu, umwanditsi uhuye na we, ni impuguke izwi muri urwo rwego. Ubu bushakashatsi bwatewe inkunga n’inkunga nyinshi zizwi, zirimo Fondasiyo y’ubumenyi y’ubumenyi y’igihugu y’Ubushinwa ndetse na Fondasiyo y’ubumenyi ya Beijing.
Ubu bushakashatsi bwibanze butanga ibimenyetso bifatika byerekana ko imiti ya IM19 CAR-T idafite akamaro gusa ahubwo ko ifite umutekano kubarwayi bafite indwara mbi ya B-selile. Itanga inzira yubushakashatsi hamwe nibishobora kuvurwa, bitanga ibyiringiro bishya kubarwayi bafite uburyo buke bwo kuvura.