Bioocus Itera Imipaka mu Kuvura Indwara Yitwa Lymphoblastique Leukemia
Intambwe ikomeye mu rwego rwo kuvura CAR-T, yaranzwe no gutangaza ubushakashatsi buherutse gukorwa buyobowe na Dr. Chunrong Tong mu bitaro bya Lu Daopei. Ubu bushakashatsi bwiswe "Inararibonye n'imbogamizi zo mu gisekuru cya kabiri CD19 CAR-T ivura Akagari muri Pediatric Acute Lymphoblastic Leukemia," gitanga isesengura ryimbitse ku mikorere n'umutekano bya CD19 CAR-T ivura ingirabuzimafatizo mu kuvura indwara zikomeye za lymphoblastique leukemia. (BYOSE).
Ubu bushakashatsi bushimangira ubushobozi bushya bwibicuruzwa bya CAR-T ya Bioocus mugukemura kimwe mubibazo by’imitsi itoroshye ku bana. Ubushakashatsi burambuye ku byavuye mu mavuriro byagaragaye ku barwayi batewe ubu buvuzi, bugaragaza ibipimo by’indwara zanduye. Icyakora, iragaragaza kandi ibibazo bikomeye, cyane cyane imicungire ya syndrome ikabije yo kurekura cytokine (CRS) hamwe na neurotoxicity, ibyo bikaba bikomeje kwibandwaho mu guteza imbere umutekano w’abarwayi.
Ubuvuzi bwa Bioocus CAR-T, bugaragara muri ubu bushakashatsi, bukoresha igisekuru cya kabiri cyongera ibikorwa bya T-selile kurwanya kanseri ya kanseri igaragaza antigen ya CD19. Ubu buryo ni ingenzi cyane mu kunesha uburyo bwo guhangana bwakunze kugaragara mu bana basubiramo cyangwa banga kuvura indwara zose. Ibisubizo byatanzwe muri iki gitabo ntibigaragaza gusa ubushobozi bwo kuvura ibicuruzwa bya CAR-T ya Bioocus ahubwo binashimangira akamaro ko guhanga udushya no gukora ubushakashatsi ku mavuriro kugira ngo tunonosore ubwo buvuzi kurushaho.
Ubushakashatsi bwa Dr. Tong bugira uruhare runini mu gushyira mu bikorwa imiti ya CAR-T kandi ihuza n'inshingano za Bioocus yo guteza imbere imiti ya kanseri binyuze mu bisubizo bigezweho. Nkumuyobozi wisi yose mu iterambere rya CAR-T, Bioocus ikomeje kwiyemeza gushyira imipaka y’ibishoboka mu kuvura kanseri, intego nyamukuru yo kuzamura umusaruro w’abarwayi n’ubuzima bwiza.
Mu gihe Bioocus ikomeje gufatanya n’ibigo by’ubuvuzi bikomeye nk’ibitaro bya Lu Daopei, dukomeje kwitangira gukemura ibibazo byagaragaye muri ubu bushakashatsi no gutunganya ibicuruzwa byacu CAR-T kugira ngo umutekano wabo unoze. Ibyo twiyemeje kuba indashyikirwa no guhanga udushya byemeza ko duhagaze neza kugira ngo tuyobore ejo hazaza h'ubuvuzi bwa kanseri.