Amakuru

Ubushakashatsi buherutse gukorwa bugaragaza akamaro ko kuvura CD7 CAR-T ikurikirwa na kabiri ya allogeneic hematopoietic stem selile transplantation (HSCT) ku barwayi barwaye T-selile acute lymphoblastique leukemia (T-ALL) na lymphoblastique lymphoma (LBL), byerekana imbaraga zikomeye muri kugera ku ndwara nkeya zisigaye (MRD) -ibisubizo byuzuye.

Ubushakashatsi bwibanze bwerekana intsinzi ndende ya CD19 CAR T-selile yubuvuzi mu kuvura abarwayi bafite lymphoblastique ikaze yisubiraho / Yongeye gukira (BYOSE) nyuma yo kwimurwa kwa allogeneic hematopoietic stem selile, bitanga ibyiringiro bishya mu kuvura indwara.

Bioocus iri ku isonga mu guteza imbere ibisekuruza bizaza CAR-T. Igitabo giherutse gukorwa na Dr. Chunrong Tong hamwe nitsinda rye mu bitaro bya Lu Daopei cyerekana iterambere n’ingorabahizi mu ishyirwa mu bikorwa ry’ubuvuzi bwa CD19 CAR-T bwo mu gisekuru cya kabiri ku barwayi b’abana, byerekana ubushake bwa Bioocus bwo kuvura kanseri.

Ubushakashatsi bwibanze bwerekana imikorere idasanzwe yubuvuzi bwa CAR-T mu kuvura B-selile Acute Lymphoblastique Leukemia (B-BYOSE). Ubushakashatsi, burimo ubufatanye n’ibitaro bya BIOOCUS n’ibitaro bya Lu Daopei, byerekana iterambere ryinshi, bishyiraho uburyo bwo kuvura nk'uburyo bukomeye bwo kuvura.

Abashakashatsi bo mu bitaro bya Lu Daopei hamwe n’abafatanyabikorwa mpuzamahanga bareba imiti igezweho ya CAR-T, itanga ibyiringiro ku barwayi bafite indwara mbi ya B. Ubu bushakashatsi bugaragaza iterambere mugushushanya no kubishyira mu bikorwa, byerekana ibisubizo bitanga icyizere hamwe nubushobozi bwo guhanga udushya.

Ubushakashatsi buherutse gukorwa ku mavuriro bugaragaza ko CD19 CAR-T ishingiye kuri 4-1BB yerekana imbaraga za antitumor ugereranije na CD28 zishingiye kuri CAR-T mu kuvura selile yisubiramo cyangwa yangiritse B selile lymphoblastique leukemia (r / r B-BYOSE).

Ubushakashatsi buherutse gukorwa mu bitaro bya Lu Daopei bwerekanye imbaraga n’umutekano mwinshi wa CD19 CAR-T ivura selile nkeya mu kuvura abarwayi banga cyangwa bongeye kwisubiramo B acute lymphoblastique leukemia (B-ALL). Ubushakashatsi bwarimo abarwayi 51, bwerekanye igipimo kidasanzwe cyo gukira hamwe n'ingaruka nkeya.

Ibitaro bya Lu Daopei na Hebei Senlang Biotechnology batangaje ibyavuye mu bushakashatsi buherutse gukorwa ku bijyanye n’umutekano n’akamaro ko kuvura CAR-T yo kuvura indwara ya selile ikaze B. Ubu bufatanye bugaragaza ubushobozi bushya bwa CAR-T igishushanyo mbonera cyo kuzamura umusaruro w’abarwayi.

Ubushakashatsi bushya buyobowe na Dr. Zhi-tao Ying wo mu bitaro bya kanseri ya kaminuza ya Peking bwerekanye umutekano n’akamaro ko kuvura selile ya IM19 CAR-T mu kuvura indwara mbi ziterwa na B-selile B-selile. Byanditswe muriIkinyamakuru cyo mu Bushinwa cy’ibiyobyabwenge bishya, ubushakashatsi buvuga ko abarwayi 11 kuri 12 bageze ku gukira burundu nta ngaruka mbi zikomeye, byerekana ubushobozi bwa IM19 nk'uburyo bwiza bwo kuvura abarwayi bafite ubundi buryo buke.

Mu myaka mirongo itanu ishize, ubushakashatsi bwakozwe ku ngirabuzimafatizo za Killer (NK) bwahinduye imyumvire yacu ku bijyanye n'ubudahangarwa bw'umubiri, butanga inzira nshya zitanga kanseri no kuvura virusi.

Amahugurwa ngarukamwaka 2024 agenga imicungire y’amaraso n’ikoranabuhanga rya Transfusion mu mujyi wa Sanhe yabereye mu bitaro bya Yanda Ludaopei. Ibi birori bigamije guteza imbere imiyoborere y’amaraso n’umutekano wo guterwa binyuze mu mahugurwa yuzuye yitabiriwe n’inzobere mu buzima zirenga 100 baturutse mu bigo bitandukanye by’ubuvuzi.

Ubushakashatsi bwibanze mu bitaro bya kaminuza ya Erlangen bwavuye neza umukobwa wimyaka 16 ufite lupus erythematosus (SLE) ikoresheje imiti ya CAR-T. Ibi birerekana uburyo bwa mbere bwo kuvura ubuvuzi bwabana bato, butanga ibyiringiro bishya kubana barwaye autoimmune.