Myasthenia gravis-02

Li Ming's Myasthenia Gravis yo Kuvura

Li Ming, umwarimu w’imyaka 35, yatangiye kubona ibimenyetso bya myasthenia gravis (MG) mu myaka itatu ishize. Mu ikubitiro, yabonye ptose (ijisho ryijimye) kandi bigoye kuvuga, ariko ibimenyetso byagendaga byiyongera buhoro buhoro intege nke zimitsi, bituma nibikorwa bya buri munsi bitoroshye. Nubwo yagiye avurwa mu buryo butandukanye, harimo na steroid na immunosuppressants, ibimenyetso bye byakomeje kugenzurwa.

Binyuze mu nshuti ye, Li Ming yageze mu bitaro bya Lu Daopei kugira ngo yitabire ibizamini bya CAR-T. Itsinda ryinzobere ryakoze isuzuma rirambuye ku bimenyetso bye kandi rimutegurira kuvura CAR-T.

Uburyo bwo kuvura:

1. Icyiciro cyo kwitegura: Mbere yo kuvurwa, Li Ming yakorewe isuzuma ryuzuye ryubuzima. Abaganga batandukanije ingirabuzimafatizo za T mu mubiri we maze bahindura genetike muri laboratoire kugira ngo bagaragaze imiti ya chimeric antigen reseptors (CAR) yibasira antigene yihariye ifitanye isano na myasthenia gravis.

2. Kwaguka kwakagari: selile CAR-T yahinduwe yaguwe muri laboratoire kugirango habeho umubare uhagije wo kuvura.

3. Imiti ya chimiotherapie: Mbere yo kwinjiza selile CAR-T, Li Ming yakoresheje icyumweru cyose cya chimiotherapie kugirango agabanye umubare wa lymphocytes zisanzwe mumubiri we, bituma habaho ahantu heza kugirango selile CAR-T ikore neza.

4. Kwinjiza CAR-T Cell: Nyuma yo kurangiza chimiotherapie, Li Ming yajyanywe mubitaro kugirango yakire selile CAR-T. Iyi nzira yakozwe ikurikiranwa cyane kugirango hirindwe ingaruka mbi.

Ibisubizo byo kuvura:

1. Igisubizo cyigihe gito: Mucyumweru cya mbere nyuma yo gushiramo, Li Ming yagize umuriro woroshye numunaniro, ibisubizo byigihe gito kubuvuzi bwa CAR-T. Nyuma y'ibyumweru bibiri, ptose ye ningorane zo kuvuga byateye imbere cyane, imbaraga zitangira kugaruka.

2. Gutezimbere mu gihe giciriritse: Nyuma y'amezi abiri, ibimenyetso bya Li Ming byari byaragabanutse cyane. Yashoboye gusubukura ibikorwa bisanzwe byo kwigisha, imikorere ye irazamuka, kandi imibereho ye yerekanaga iterambere ryinshi.

3. Ingaruka z'igihe kirekire: Amezi atatu nyuma yo kuvurwa, Li Ming ntagishingiye ku miti yabanje. Ibizamini byakurikiranwe byagaragaje ko sisitemu y’umubiri yari imeze neza, nta ngaruka zikomeye zagaragaye.

Binyuze mu kuvura selile CAR-T, gravis myasthenia ya Li Ming yagenzuwe cyane. Li Ming amarira arira, aterura ukuboko kwa muganga amaze gusohoka, yagize ati: "Nishimiye cyane ubuvuzi bwa CAR-T hamwe n'itsinda ry’abaganga bitanze ku bw'imbaraga zabo."