Myasthenia gravis-01

Zhang Wei's Myasthenia Gravis yo Kuvura

Zhang Wei, injeniyeri wa software ufite imyaka 32, yatangiye kubona ibimenyetso bya myasthenia gravis (MG) hashize imyaka ibiri. Ku ikubitiro, yari afite ptose (ijisho ryijimye) kandi atabona neza, ariko ibimenyetso bye byarushijeho kwiyongera uko igihe cyagiye gihita, bituma intege nke zimitsi zagize ingaruka zikomeye kumurimo we no mubuzima bwa buri munsi. Nubwo yagiye avurwa bitandukanye, harimo imiti ya anticholinesterase, immunosuppressants, na immunoglobuline yinjira mu maraso, ibimenyetso bye byakomeje kandi bikunze kugaruka.

Hamwe nubuvuzi gakondo bugaragaza ko butagize icyo bugeraho, abaganga basabye ko Zhang Wei yagerageza uburyo bushya bwo kuvura: CAR-T ivura selile. Ubu buryo bushya bwo kuvura bukoresha ingengabihe yo guhindura ingirabuzimafatizo T z'umurwayi, zibafasha kwibasira no gukuraho selile zidasanzwe zifitanye isano n'indwara.

Nyuma yo gusuzuma neza, Zhang Wei yasanze akwiriye kuvurwa. Abaganga babanje gutandukanya selile T mumubiri we bahindura genetike barayagura muri laboratoire. Zhang Wei yahise akorerwa chimiotherapie kugirango agabanye lymphocytes zisanzwe mu mubiri we, yitegura kwinjiza selile CAR-T. Hanyuma, selile CAR-T yahinduwe yongeye gushyirwa mumubiri wa Zhang Wei.

Mu cyiciro cya mbere cyo kuvura, Zhang Wei yagize umunaniro muto, ariko nyuma y'ibyumweru bibiri, ibimenyetso bye byatangiye kumera neza. Indwara ya ptose no kutabona neza yagabanutse cyane, imbaraga ze ziragaruka buhoro buhoro. Ukwezi kumwe, imikorere ye yarateye imbere, kandi ashobora gukomeza imirimo isanzwe ya buri munsi. Amezi atatu nyuma yo kuvurwa, ibimenyetso bya Zhang Wei byari byarazimye burundu, kandi ntiyari agikeneye imiti yabanje. Ibizamini byakurikiranye byagaragaje ko ubudahangarwa bw'umubiri we bumeze neza, nta ngaruka mbi cyangwa ibimenyetso by’indwara byongeye kubaho.

Binyuze mu kuvura selile CAR-T, gravis ya myasthenia ya Zhang Wei yagenzuwe cyane, bituma ubuzima bwe nubushobozi bwakazi akora. Ubu buvuzi butanga ibyiringiro bishya kubarwayi benshi ba myasthenia gravis.