Multi Myeloma hamwe na Plasmacytoma idasanzwe

Nibibazo byumurwayi wumugabo wimyaka 73 wasuzumwe na myeloma nyinshi, bigoye no kuba plasmacytoma idasanzwe. Mu gihe cyose cyo kuvura hamwe na Dara-VRD (Daratumumab, Bortezomib, Lenalidomide, Dexamethasone), plasmacytoma ikabije yarakomeje, itera ububabare bukabije n’umurwayi.

Urebye imiterere y’indwara ndetse no kutitabira imiti isanzwe, umurwayi yanditswe mu igeragezwa ry’amavuriro ya BCMA CAR-T ivura selile. Nyuma yo gutera intambwe zikenewe zo kwitegura, harimo na lymphodepletion, umurwayi yakiriye ingirabuzimafatizo za BCMA CAR-T.

Igitangaje, muminsi 10 nyuma yo gushiramo, umurwayi yagize syndrome ya kabiri ya cytokine irekura syndrome (CRS), byerekana imbaraga z'umubiri zikomeye. Byongeye kandi, hari CRS igaragara cyane kurubuga rwa plasmacytoma idasanzwe.

Igitangaje kurushaho ni uko muri iki gihe gito, mbere y’indwara zanduye zidakira, zari zaragaragaye ko zihanganira imirongo myinshi ya chimiotherapie, imiti igamije, na antibodiyite za monoclonal, yazimiye burundu. Umurwayi yageze ku gukira byuzuye, byerekana intsinzi yo kuvura.

Muri gahunda zose zo kuvura, itsinda ryubuvuzi ryakurikiraniraga hafi umurwayi ibimenyetso byose byerekana ingaruka mbi kandi bitanga ubuvuzi bwuzuye. Ibi byari bikubiyemo gucunga ibimenyetso bya CRS no gukemura izindi ngorane zose zijyanye no kuvura.

Mu gihe ubuvuzi bwagendaga butera imbere, itsinda ry’abaganga ryakomeje gukurikiranira hafi uko umurwayi yakira imiti ya BCMA CAR-T. Isuzuma risanzwe ryakozwe kugirango harebwe akamaro ko kuvura no gukemura ingaruka zose zigaragara vuba.

Nyuma yo kugera ku buryo butangaje bwo gukira burundu, ubuzima bw’umurwayi bwateye imbere ku buryo bugaragara, hamwe no kugabanya ububabare n’uburangare bujyanye na plasmacytoma idasanzwe. Iyo ndwara igenzurwa, umurwayi yashoboye gukomeza ibikorwa bya buri munsi kandi yishimira ubuzima bwiza muri rusange.

Byongeye kandi, tumaze kumenya akamaro ko gukurikiranwa igihe kirekire, itsinda ryacu ryubuvuzi ryakomeje kugira uruhare rugaragara mu rugendo rw’umurwayi nyuma yo kuvurwa. Gahunda yo gukurikirana buri gihe yari iteganijwe gukurikirana uko umurwayi ameze, gusuzuma igihe kirekire cyo kuvura, no gukemura ingaruka zose zishobora kubaho cyangwa gutinda gutangira.

Usibye gukurikirana ubuvuzi, ikigo cyacu cyatanze serivisi zuzuye zifasha umurwayi kumenyera ubuzima nyuma yo kuvurwa. Ibi byari bikubiyemo kubona serivisi zubujyanama, gahunda zo gusubiza mu buzima busanzwe, hamwe n’ibikoresho by’uburezi bifasha umurwayi n’umuryango wabo kuyobora ubuzima bwabo no gukomeza ubuzima bwiza.

Intsinzi yuru rubanza ntabwo yerekana gusa akamaro ko kuvura selile ya BCMA CAR-T mu kuvura myeloma yangiritse ariko inagaragaza akamaro ko kwitabwaho kugiti cyihariye kandi kinyuranye mugucunga indwara mbi ziterwa na hematologiya. Ibyo twiyemeje gutanga ubufasha buhoraho no kubikurikirana byerekana ubwitange bwacu mugushakisha ibisubizo byiza bishoboka kubarwayi bacu birenze icyiciro cyo kuvura.

Mbere & 3 amezi nyuma yo gushiramo