Multi Myeloma (MM) -01

Gusubirana neza kwa Multi Myeloma Yumurwayi Mumurwayi hamwe na CAR-T Ubuvuzi Nubura BCMA Yerekana

Umurwayi wumugore wasuzumwe icyiciro cya IIIA IgD-λ ubwoko bwinshi bwa myeloma muri 2018 yakiriye umurongo wambere cyane cyane na bortezomib. Nyuma yinzinguzingo 3, yageze kubisubizo byuzuye (CR). Mu Kwakira 2018, yatewe na autologique hematopoietic stem selile transplantation yo kuvura hamwe, hanyuma akurikiranwa no kuvura lenalidomide. Muri Mata 2020, indwara yongeye kugaruka, maze akorerwa inzinguzingo 7 zo kuvurwa ku murongo wa kabiri, bitanga umusaruro muke. Kuva mu Kuboza 2020 kugeza muri Mata 2021, yakiriye chimiotherapie cyane cyane na daratumumab, ariko biopsy yo mu magufa iracyerekana 21.763% ya selile mbi ya monoclonal plasma, hamwe na serumu yubusa ya serumu λ kuri 1470 mg / L hamwe n’umucyo utagira inkari λ kuri 5330 mg / L. Kugeza magingo aya, yari amaze kunaniza uburyo bukomeye bwo kuvura no kuvura ibintu biboneka mu gihugu, harimo no guterwa insimburangingo ngengabuzima ya autologique, hamwe no kwinjira mu mavuriro ya CAR-T aribwo buryo bwiza busigaye.

Yavuzwe n'abaganga baho, yagejeje ku bitaro bya Ludaopei ku ya 10 Gicurasi 2021, yizeye ko baziyandikisha mu mavuriro yabo kugira ngo bavurwe na BCMA CAR-T ivura indwara ya myeloma (MM). Amaze kwinjira, yari afite intege nke afite ububabare rusange hamwe numuriro mwinshi. Ibizamini byuzuye byemeje "myeloma nyinshi, type ubwoko bwurumuri rwumucyo, icyiciro cya ISS icyiciro cya gatatu, R-ISS icyiciro cya III, itsinda rya mSMART rifite ibyago byinshi."

Isuzuma rya PET-CT ryagaragaje ibikorwa byongera metabolike mu bworoherane bwimitsi mu mitsi yo mu magufa ya femur na tibiya byombi, byerekana uruhare rwibibyimba. Amagufwa ya marrow biopsy yerekanaga 60.13% ingirabuzimafatizo mbi ya plasma ya monoclonal idafite imvugo ya BCMA.

Ibitaro bya Ludaopei byamenyesheje umurwayi n’umuryango we ibijyanye n’uburyo bwiza bwo kuvura indwara ya BCMA-mbi ya myeloma myinshi, nubwo ishobora kuba nziza ukurikije ibitabo bimwe na bimwe, idafite amakuru afatika. Nyuma yo kubitekerezaho neza, umurwayi n'umuryango we bahisemo gukomeza gahunda yo kuvura.

Nyuma yo kubanziriza gahunda ya FC, selile BCMA CAR-T yatewe ku ya 1 Kamena 2021, mu bitaro bya Ludaopei. Umurwayi yagize umuriro nyuma yo gushiramo, wagiye ugenzurwa buhoro buhoro hakoreshejwe uburyo bwo kurwanya indwara zanduza no kuvura ibimenyetso. Iminsi cumi n'ine nyuma yo gushiramo, biopsy yo mu magufa yerekanaga nta selile mbi ya monoclonal plasma selile. Iminsi mirongo itatu n'umwe nyuma yo gushiramo, biopsy yo mu magufa yagumye ari mibi. Gukingira serumu byari bibi, serumu yubusa yumucyo λ yari murwego rusanzwe, na serumu M proteine ​​yari mbi, byerekana ko indwara yakuweho burundu.

Kugeza ubu, amezi arenga 8 nyuma yo guhabwa selile ya BCMA CAR-T, umurwayi akomeza kumererwa neza hamwe no gukira neza no kunyurwa cyane nubuvuzi.