Junaid ---- Acute B-lymphocytike Leukemia (B-BYOSE)

CAR-T ivuriro ryikigereranyo ikiraro amagufa transplantation itera B-BURUNDU indwara zabarwayi kubuntu mubitaro bya Lu Daopei.

Imyaka itanu irashize, Junaid yari umunyeshuri muri kaminuza yubuvuzi ya Pakisitani, yuzuye ibyifuzo byo kuba umuganga. Ariko muri Gicurasi 2014, bamusanganye indwara ya B-lymphocytic leukemia ikaze, biba ngombwa ko areka kwiga.

Yavuriwe mu karere imyaka irenga ibiri. Muri Mutarama 2018, yongeye kugira ububabare bw'amagufwa kandi isuzuma ry'amagufwa ryerekanaga ko yasubiye inyuma. Nyuma yamasomo ya kabiri ya chimiotherapie mubitaro byaho, ntabwo yashoboye gukira kandi indwara yariyongereye. Binyuze mu gushakisha kuri interineti no kubisabwa n’abandi barwayi, bahisemo kuza mu bitaro bya Lu Daopei kugira ngo basuzume ivuriro rya CART ryo ku rwego rwo hejuru na BMT.

Ku ya 26 Werurwe 2018, Junaid n'umuryango we baje mu Bushinwa maze binjira mu ishami rusange ry’imitsi y’ibitaro bya Lu Daopei. Dr Peggy Lu na Dr Junfang Yang bakoze isuzuma ryuzuye kuri Junaid. Raporo yerekanaga ko umutwaro wo guturika amagufwa wari hejuru ya 69% kandi yari afite indwara zifata ibihaha. Nyuma yo kuvurwa neza, umurwayi yari ameze neza. Ku ya 24 Mata 2018, Junaid yongeye gushyirwamo selile ebyiri CD19 & CD22 CAR-T. Nyuma yibyumweru bibiri, igufwa ryamagufa yabaga yari 0. Inseko yasubiye mumuryango wa Junaid. Junaid yagombaga gukorerwa BMT kugirango adafite indwara.

Ku ya 25 Kamena 2018, Dr Yue Lu, umuyobozi w'ishami rya BMT, hamwe n'itsinda ry'abaganga rya Dr Fang Xu bakoze umuvandimwe BMT kuri Junaid. Umuterankunga wa Junaid ni murumuna we. ku ya 6 Nyakanga, ingirangingo z'umuterankunga peripheral zongeye gusubizwa muri Junaid, nyuma y'iminsi 17 transplant selile y'amaraso yera irangiye maze ava mu cyumba cy’amazi cya laminari. Nyuma yiminsi 24, ubwoko bwamagufwa ye arahuye rwose nubwoko bwumuterankunga. Isubiramo rya raporo isigara ya magufa ya raporo ni mabi, nta kibazo kijyanye no guhindurwa hakiri kare. Ku ya 6 Kanama 2018, Junaid yavuye mu bitaro atangira kubakurikirana.

Ishirahamwe ryamaraso ryabashinwa ninkunga ikomeye yumurwayi Junaid ni ubwoko bwa RH bubi bwamaraso, nubwoko bwamaraso budasanzwe. Yemeye "Lang Fang idasanzwe y'ubwoko bw'amaraso" gutanga amaraso ku buntu inshuro nyinshi mu bitaro. Ntabwo bisa nkaho ari ibura ry'amaraso kuri we, Junaid n'umuryango we barashima cyane ikigo mpuzamahanga cyo gukorera ibyo byose Junaid. Hagati aho, abakozi b'ikigo mpuzamahanga baherekeje Junaid n'umuryango we kuva bamanuka kugeza ubu, babaha ubuzima bwose kandi bafasha umuryango gutsinda imbogamizi y'ururimi.

Ikigeragezo cyamavuriro CAR-T kiraro BMT kugirango ikore ikindi gitangaza. Ishami rya BMT ryibitaro bya Lu Daopei nimwe mubigo bikora cyane bya BMT ku rwego mpuzamahanga. Junaid numurwayi wa kabiri wongeye kwisubiraho kandi wangiritse umurwayi wa leukemia B-lymphocytike ukomoka muri Pakisitani wakiriye CAR-T Bridge BMT. Gusohoka kwa Junaid mu bitaro byongeye kwerekana ko ibihugu by’ikoranabuhanga byateye imbere mu buhanga bwo gutera ikiraro CAR-T.