Diffuse Kinini B-selile Lymphoma (DLBCL)

Uyu murwayi, umutegarugori wihanganye ufite imyaka hafi 80, yahuye nubutwari ahura nisuzuma rya Diffuse Large B-selile Lymphoma (DLBCL), agaragaza ubutwari budasanzwe murugamba rwe rwo kurwanya ubu bwoko bwa kanseri.

Nubwo yari ageze mu za bukuru, yakomeje kwiyemeza gutsinda ibibazo byatewe n'uburwayi bwe. Icyakora, mu gihe cy'amezi atandatu nyuma yo gukira hakoreshejwe imiti yo ku murongo wa mbere, yahuye n'ikibazo cyo gusubira inyuma, ashimangira imiterere y'indwara ye. Nubwo yagerageje inshuro nyinshi uburyo bwo kuvura umurongo wa kabiri n'uwa gatatu, kanseri ye yerekanaga kunangira umutima, bikaba ikibazo gikomeye ku itsinda rye ry'ubuvuzi.

Itsinda ry'ubuvuzi rimaze kubona ko ibintu byihutirwa, itsinda ry’abaganga ryatangiye gushaka ubundi buryo bwo kuvura. Uyu murwayi yiyandikishije mu igeragezwa ry’amavuriro akora iperereza kuri CD19 + 22 CAR-T ivura ingirabuzimafatizo, uburyo bugezweho bukoresha ingirabuzimafatizo za T zikoresheje ingirabuzimafatizo za kanseri zigaragaza antigene zihariye.

Ibisubizo ntakintu cyari kigufi kidasanzwe. Ukwezi kumwe gusa gukurikira kwinjizamo CD19 + 22 CAR-T, umurwayi yagezeho neza. Iyi ngaruka ikomeye ntiyabujije gusa indwara ye ahubwo yanatumye kurandura burundu ingirangingo za kanseri, ibyo bikaba ari umwanya w'ingenzi mu rugendo rwe rwo kwivuza.

Muri gahunda zose zitoroshye, itsinda ryubuvuzi ryatanze ubufasha butajegajega no kwita kumurwayi. Kuva bakurikiranira hafi igisubizo cye kubuvuzi kugeza gucunga ibibi byose, baremeje ko ubuzima bwe bukomeza kuba icyambere.

Yatekereje ku byamubayeho, umurwayi yagaragaje ko ashimira byimazeyo ubwitonzi yagize. Ati: "Ubwitange n'ubuhanga bw'itsinda ryanjye ry'ubuvuzi byari bidasanzwe rwose." "Uburyo bwabo bwo kwivuza bwampaye ibyiringiro igihe nari nkeneye cyane."

Ibisubizo byiza bya CD19 + 22 CAR-T ivura ingirabuzimafatizo mu kugera ku buryo bwuzuye byerekana ubushobozi bwayo nk'uburyo bwiza bwo kuvura abarwayi ba DLBCL bananirwa. Uru rubanza rugaragaza imbaraga zubuvuzi bushya nubuvuzi bwihariye mugucunga kanseri zikomeye, cyane cyane kubarwayi bageze mu zabukuru nkuyu mugore wintwari.

Mbere & 1 ukwezi nyuma yo gushiramo