Diffuse nini ya B-selile lymphoma (DLBCL), NOS, GCT subtype, primaire yibanze ya nervous lymphoma-01

Ukuboza 2019, Bwana Wang, umwarimu ukomoka mu majyaruguru y'uburasirazuba bw'Ubushinwa, yatangiye kurwara umutwe. Ku ya 19 Ukuboza 2019, ibizamini byo kwisuzumisha byagaragaje ibi bikurikira: PET-CT yerekanye igicucu cyinshi kandi cyiyongereye cyane metabolisme ya FDG mu gice cy’ibumoso cy’imbere hamwe na corpus callosum ivi (hafi cm 3.4 * 1,9 cm, SUVmax = 34.4). Biopsy na immunohistochemie yemeje ko ikwirakwiza lymphoma nini ya B-selile (DLBCL, NOS, GCB subtype), hamwe na immunophenotype yerekana Ki67 (50% +), CD19 (+), CD20 (+), PAX5 (+), CD79 (+), MUM1 (+), BCL (+), CD10 (- / +), CD2 (nto +). Isesengura rya Cerebrospinal fluid ryerekanye 6% selile lymphoide idakuze hamwe na morphologie variable. Isuzuma ryibanze rya lymphoma yibanze (DLBCL, subtype ya GCB).

Nyuma yo gukora ubushakashatsi ku buryo bwo kwivuza kuri interineti, Bwana Wang yamenye ibijyanye n’ubushobozi bwo gukingira ibitaro bya Lu Dao Pei maze ahita ashakisha ubuhanga bwabo. Nyuma yisuzumabumenyi ryimbitse n’isesengura ryakozwe nitsinda ry’impuguke z’ibitaro, hemejwe ko Bwana Wang azitabira igeragezwa ry’amavuriro yo kuvura CART, cyane cyane akoresheje selile CD19 CART. Yakiriye CD19 CAR-T ya selile yatewe ku ya 24 Mata 2023. Kugeza ku ya 30 Nyakanga 2023, yasuzumwe ko yakiriye neza (CR) kandi kuva icyo gihe yasubiye mu buzima busanzwe.