Incamake Yuzuye yo Kuvura Indwara ya Leukemia

Ubuvuzi bwa CAR-T, bugufi kuri Chimeric Antigen Receptor T-Cell Immunotherapy, nuburyo bwambere bwo kuvura gene burimo guhindura genetike ya selile T umurwayi kugirango yibasire kandi isenye kanseri ya kanseri. Bitandukanye n'imiti gakondo, ubuvuzi bwa CAR-T bujyanye na buri murwayi kandi busaba gukusanya selile T mumaraso yumurwayi mbere yo kuyasubiza mumubiri nyuma yubuhanga bwa geneti.

Twandikire

Ibimenyetso bya CAR-T

●B-selile acute lymphoblastique leukemia

●Myeloma nyinshi

●Indwara ya lymphocytike idakira

●Lymphoma itari Hodgkin

●Diffuse nini ya B-selile lymphoma

●SLE （Sisitemu Lupus Erythematosus）

●Myasthenia gravis

●Izindi ndwara ziterwa na autoimmune

Imikorere myiza ya CAR-T ivuriro

Ibyerekana CD19 + 20CAR-T:Abarwayi bafite lymphoma ya B-selile itari Hodgkin

Ukwezi kumwe igipimo cya CR	Ukwezi kumwe igipimo cya PR	Ukwezi kumwe cyangwa igipimo	CRS≥3	CRES≥3
71,95% (59/82)	25.6 (21/82)	97.55 (80/82)	12.19% (10/82)	0

Ibyerekana CD19 + 22CAR-T:Umuti wa CD19 wongeye kwisubiraho no gukara abarwayi ba leukemia B-lymphocytike

Ukwezi kumwe igipimo cya CR	Ukwezi kumwe igipimo cya PR	Ukwezi kumwe cyangwa igipimo	CRS≥3	CRES≥3
92.1% (35/38)	7.9% (3/38)	100% (38/38)	15,79% (6/38)	0

Ibyerekana kuri BCMACAR-T:Umuti wongeye gusubiramo no kwanga myeloma myinshi

Ukwezi kumwe igipimo cya CR	Ukwezi kumwe igipimo cya PR	Ukwezi kumwe cyangwa igipimo	CRS≥3	CRES≥3
72.41% (21/29)	27.59% (29/8)	100% (29/29)	6.9% (29/2)	0

Ibyiza byacu

● Umuti Wihariye: Buri muti wa CAR-T wateguwe kumurwayi, ukemeza neza ibisubizo byiza kandi bivura.

● Amahitamo atandukanye: Hamwe na antigene zitandukanye zigamije, harimo CD7, CD19, CD20, CD22, na BCMA, ibicuruzwa byacu CAR-T bitanga ibintu byinshi bitagereranywa mukuvura indwara mbi ziterwa na hematologiya n'indwara ziterwa na autoimmune.

● Intsinzi yubuvuzi bwagaragaye.

● Igiciro Cyinshi-Cyiza: Dutanga amahirwe yo gupiganwa hamwe nubuvuzi buhanitse bwo kuvura kubiciro byoroshye ugereranije nibindi bicuruzwa CAR-T ku isoko.

● Gukata-Ikoranabuhanga: Twifashishije iterambere rigezweho mu buhanga bwa genetike, imiti yacu CAR-T ikubiyemo ejo hazaza ha kanseri no kuvura indwara ziterwa na autoimmune.

● Inkunga y'inzobere: Itsinda ryacu ry'inararibonye ry'abaganga n'abashakashatsi ritanga ubuvuzi bwuzuye uhereye kubujyanama bwambere binyuze mubuyobozi bwo kuvura no kubikurikirana.

Ingirabuzimafatizo za CAR-T ubu zizwi cyane kubera imikorere yazo ku barwayi batitabira imiti gakondo nka chimiotherapie cyangwa transplantation yo mu magufa. Umuryango w’ubuvuzi ku isi uremera ubushobozi bukomeye bwo kuvura CAR-T mu guhindura umusaruro w’abarwayi.

ibisobanuro2

Fill out my online form.