Bjørn Simensen ---- Multi Myeloma (IgG lambda) ISS-II

Twishimiye patient Umurwayi ukomoka muri Noruveje, Bjørn Simensen, ufite imyaka ibiri yo gukira neza.

Bjørn Simensen w'imyaka 67 y'amavuko yashyikirije ibitaro muri Nzeri 2017 ibirego byo gukorora no kubabara mu gatuza. Mugihe yakoraga, basanze afite myeloma nyinshi (IgG lambda) ISS-II. Umurwayi yakiriye inzinguzingo 4 za bortezomib, lenalidomide na chimiotherapie dexamethasone. Kohereza inzinguzingo 4 proteine ​​ye M yari munsi ya 1g / l. Umurwayi yahise asohoka kubungabunga lenalidomide (ibyumweru 10mg qdx3 kumwezi m) akomeza mumyaka 2 yakurikiye. Yakomeje kutagira indwara kugeza mu mpeshyi yo mu 2021 igihe yasuzumaga imiti yasanze yazamuye poroteyine M (5g / l). Lenalidomide yarahagaritswe atangira kuri chimiotherapie ya carfilzomib na daratumumab kuva mu Kwakira kugeza Ukuboza 2021. Icyakora, chimiotherapie ntiyagize icyo ikora kandi nyuma ya chemo BM MRD yari nziza.

Bwana Bjørn Simensen yagaragaye bwa mbere mu bitaro bya Lu Daopei ku ya 14 Gashyantare 2022. BM MRD ye yerekanye 0,25 ku ijana by'ingirabuzimafatizo zidasanzwe. IEF yerekanye IgG na M proteine ​​yari 3 g / l. PET-CT Scan yerekanye kwiyongera kwinshi muri testis cyane cyane iburyo nabwo bwaguwe mubizamini. Hakozwe biopsy ya testicular yerekana selile mbi. Umurwayi yatoranijwe kugirango avure selile. Preconditioning yakozwe na fludarabine na cyclophosphamide muminsi 3. Ingirabuzimafatizo za CAR-T zashyizwe ku munsi wa 0 (4/3/2222). Igipimo cyatanzwe cyari 0.5X10 ^ 6 / kg. Nyuma yo gushiramo, umurwayi yagize umuriro wa neutropenia wagenzurwaga na iv antibiotique. Kubyimba kwa testicular iburyo buhoro buhoro bigabanuka kugeza mubunini busanzwe. Ku munsi wa 28 ikizamini cya BM cyari kibi kuri selile. Umurwayi yasohotse muri Lu Daopei akurikiranwa buri gihe mu kigo cy’amaraso mu mujyi we.